Title:
DNA-DAMAGE-INDUCED PROTEOLYSIS
Document Type and Number:
WIPO Patent Application WO/2010/065927
Kind Code:
A3
Abstract:
The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt.
Inventors:
KHOSHNAN ALI (US)
PATTERSON PAUL H (US)
PATTERSON PAUL H (US)
Application Number:
PCT/US2009/066874
Publication Date:
November 04, 2010
Filing Date:
December 04, 2009
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
KHOSHNAN ALI (US)
PATTERSON PAUL H (US)
KHOSHNAN ALI (US)
PATTERSON PAUL H (US)
International Classes:
C12Q1/02; C12N5/0793; G01N33/15
Other References:
KHOSHNAN, A. ET AL.: "IKKalpha and IKKbeta regulation of DNA damage of huntingtin.", PLOS ONE, vol. 4, no. 6, 2 June 2009 (2009-06-02), pages 1 - 10
KHOSHNAN, A. ET AL.: "Activation of IkappaB kinase complex and nuclear factor-KB contributes to mutant huntingtin neurotoxicity.", J. NEUROSCI., vol. 24, no. 37, 15 September 2004 (2004-09-15), pages 7999 - 8008
MATTSON, M. P. ET AL.: "Roles for NF-KB in nerve cell survival, plasticity, and disease.", CELL DEATH AND DIFFERENTIATION, vol. 13, 6 January 2006 (2006-01-06), pages 852 - 860
GHOSH, A. ET AL.: "Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.", P.N.A.S, vol. 104, no. 47, 20 November 2007 (2007-11-20), pages 18754 - 18759
KHOSHNAN, A. ET AL.: "Activation of IkappaB kinase complex and nuclear factor-KB contributes to mutant huntingtin neurotoxicity.", J. NEUROSCI., vol. 24, no. 37, 15 September 2004 (2004-09-15), pages 7999 - 8008
MATTSON, M. P. ET AL.: "Roles for NF-KB in nerve cell survival, plasticity, and disease.", CELL DEATH AND DIFFERENTIATION, vol. 13, 6 January 2006 (2006-01-06), pages 852 - 860
GHOSH, A. ET AL.: "Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.", P.N.A.S, vol. 104, no. 47, 20 November 2007 (2007-11-20), pages 18754 - 18759
Attorney, Agent or Firm:
ALTMAN, Daniel, E. (Martens Olson & Bear, LLP,2040 Main Street, 14th Floo, Irvine CA, US)
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