Title:
DNA DELIVERY SYSTEM USING EXOSOME AS VECTOR
Document Type and Number:
WIPO Patent Application WO/2023/185261
Kind Code:
A1
Abstract:
Provided is a DNA delivery system using an exosome as a vector. The DNA delivery system comprises a DNA packaging system and a targeted delivery vector. The DNA packaging system can introduce a DNA sequence with a modified RNF112 gene into the exosome, and the obtained exosome can be administered to a subject to treat ALS.
Inventors:
YIN LE (CN)
GU YUCHUN (CN)
WU LIDA (CN)
GU YUCHUN (CN)
WU LIDA (CN)
Application Number:
PCT/CN2023/075044
Publication Date:
October 05, 2023
Filing Date:
February 08, 2023
Export Citation:
Assignee:
ALLIFE REGENERATIVE MEDICINE TECH ZHUHAIHENGQINXINQU CO LTD (CN)
International Classes:
A61K38/17; C12N15/62; A61K48/00; A61P21/00; C07K19/00; C12N5/10; C12N15/87
Foreign References:
| CN114606251A | 2022-06-10 | |||
| CN109983124A | 2019-07-05 | |||
| CN113527519A | 2021-10-22 | |||
| CN107034188A | 2017-08-11 |
Other References:
DATABASE Nucleotide 26 June 2021 (2021-06-26), ANONYMOUS : "Homo sapiens ring finger protein 112 (RNF112), mRNA", XP093097065, retrieved from NCBI Database accession no. NM_007148.5
ZHANG, FENG ET AL.: "Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription", NATURE BIOTECHNOLOGY, vol. 29, no. 2, 19 January 2011 (2011-01-19), XP055005146, ISSN: 1087-0156, DOI: 10.1038/nbt.1775
ZHANG, FENG ET AL.: "Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription", NATURE BIOTECHNOLOGY, vol. 29, no. 2, 19 January 2011 (2011-01-19), XP055005146, ISSN: 1087-0156, DOI: 10.1038/nbt.1775
Attorney, Agent or Firm:
BEIJING ZHI CHENG HAN FANG IP AGENCY CO., LTD. (CN)
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