Title:
DNA METHYLATION ANALYSIS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF ADRENAL NEOPLASMS
Document Type and Number:
WIPO Patent Application WO/2013/148147
Kind Code:
A8
Abstract:
Disclosed herein are methods for detecting, diagnosing and/or prognosing a malignant adrenocortical tumor. Also disclosed are methods of treating a malignant adrenocortical tumor, such as ACC. In some examples, the method of diagnosing and/or prognosing includes obtaining a sample comprising genomic DNA from a subject at risk of acquiring or suspected to have an adrenocortical tumor; isolating genomic DNA from the sample; and measuring the level of one or more methylated genomic CpG dinucleotide sequences in one or more of the adrenocortical genomic targets in the sample, wherein an increase in the level of methylation of the one or more genomic CpG dinucleotide sequences in the sample compared to a control indicates a malignant adrenocortical tumor.
Inventors:
KEBEBEW ELECTRON (US)
RECHACHE NESRINE S (US)
MELTZER PAUL S (US)
WANG YONGHONG (US)
RECHACHE NESRINE S (US)
MELTZER PAUL S (US)
WANG YONGHONG (US)
Application Number:
PCT/US2013/030347
Publication Date:
November 14, 2013
Filing Date:
March 12, 2013
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
C12Q1/68
Attorney, Agent or Firm:
BRADLEY, Karri, Kuenzli (LLPOne World Trace Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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