DNA MOLECULE CODING CHIMERIC ZIKA VIRUS AND PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2018/214692

A1

Provided are a DNA molecule coding a chimeric Zika virus and a preparation method therefor and a use thereof. The DNA molecule comprises the following sequences linked in tandem: a sequence of a 5' non-coding region, a coding sequence of capsid protein C, a coding sequence of a membrane protein precursor, a coding sequence of an envelope (E) protein α lacking three amino acid residues at the carboxy terminus, and a coding sequence of three amino acid residues at the carboxy terminus of an envelope (E) protein β, a coding sequence of a non-structural protein NS, and a sequence of a 3' non-coding region, the coding sequence of the membrane protein precursor and the coding sequence of envelope (E) protein α being derived from a Zika virus, and the remaining sequences being derived from an attenuated strain of a Japanese encephalitis virus.

QIN CHENGFENG (CN)
LI XIAOFENG (CN)
WANG HONGJIANG (CN)

PCT/CN2018/084610

November 29, 2018

April 26, 2018

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BEIJING INST OF MICROBIOLOGY AND EPIDEMIOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES (CN)

C12N7/01; A61K39/12; A61P31/14; C12N1/19; C12N5/10; C12N15/63; C12N15/85; C12R1/93

CN103352029A	2013-10-16
CN103409376A	2013-11-27
CN103088049A	2013-05-08

LI, XF ET AL.: "Development of a Chimeric Zika Vaccine Using a Licensed Live-Attenuated Flavivirus Vaccine as Backbone", NATURE COMMUNICATIONS, vol. 9, no. 1, 14 February 2018 (2018-02-14), pages 1 - 11, XP055549640, ISSN: 2041-1723
DATABASE GenBank [O] 24 May 2016 (2016-05-24), XP055549645, Database accession no. ARM39834 . 1

RUNPING & PARTNERS (CN)

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