Title:
DNA NANOROBOT AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/109707
Kind Code:
A1
Abstract:
Provided is a DNA nanostructure nanorobot comprising: a single stranded DNA scaffold strand of about 5,000 to 10,000 bases in length; a plurality of staple strands of DNA, wherein each staple strands are about 20 to 40 bases in length, wherein each staple strand has a unique sequence and is hybridized to a specific position on the DNA scaffold strand, wherein the plurality of staple strands hybridized to the DNA scaffold form a sheet having a top surface and a bottom surface; and one or more fastener strands of DNA, wherein the one or more fastener strands of DNA are capable of fastening the sheet into an origami structure.
Inventors:
YAN HAO (US)
JIANG QIAO (CN)
LI SUPING (CN)
DING BAOQUAN (CN)
NIE GUANGJUN (CN)
JIANG QIAO (CN)
LI SUPING (CN)
DING BAOQUAN (CN)
NIE GUANGJUN (CN)
Application Number:
PCT/CN2018/106742
Publication Date:
June 13, 2019
Filing Date:
September 20, 2018
Export Citation:
Assignee:
UNIV ARIZONA STATE (US)
NAT CT NANOSCIENCE & TECHNOLOGY CHINA (CN)
NAT CT NANOSCIENCE & TECHNOLOGY CHINA (CN)
International Classes:
C12N15/11
Domestic Patent References:
| WO2017089570A1 | 2017-06-01 | |||
| WO2015048429A1 | 2015-04-02 | |||
| WO2016025719A1 | 2016-02-18 |
Foreign References:
| CN106893722A | 2017-06-27 | |||
| CN101744645A | 2010-06-23 |
Other References:
HONG, F. ET AL.: "DNA Origami: Scaffolds for Creating Higher Order Structures", CHEMICAL REVIEWS, vol. 117, no. 20, 12 June 2017 (2017-06-12), pages 12584 - 12640, XP055474939
LINKO, V. ET AL.: "DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices", BIOTECHNOLOGY, vol. 33, no. 10, 31 October 2015 (2015-10-31), pages 586 - 594, XP029279689, DOI: 10.1016/j.tibtech.2015.08.001
BENJAMIN KICK ET AL.: "Efficient Production of Single-Stranded Phage DNA as Scaffolds for DNA Origami.", NANO LETTERS., vol. 15, no. 7, 1 June 2015 (2015-06-01), pages 4672 - 4676, XP055347289, DOI: 10.1021/acs.nanolett.5b01461
LINKO, V. ET AL.: "DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices", BIOTECHNOLOGY, vol. 33, no. 10, 31 October 2015 (2015-10-31), pages 586 - 594, XP029279689, DOI: 10.1016/j.tibtech.2015.08.001
BENJAMIN KICK ET AL.: "Efficient Production of Single-Stranded Phage DNA as Scaffolds for DNA Origami.", NANO LETTERS., vol. 15, no. 7, 1 June 2015 (2015-06-01), pages 4672 - 4676, XP055347289, DOI: 10.1021/acs.nanolett.5b01461
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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