Title:
DNA-PEPTIDE COMPOSITE COMPRISING HIGH-DENSITY FUNCTIONAL GROUP, DNA-PEPTIDE-NANOMATERIAL COMPOSITE AND PREPARATION METHOD THEREFOR, AND DNA-METAL NANOWIRE AND MANUFACTURING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/080273
Kind Code:
A1
Abstract:
Disclosed are a DNA-peptide composite comprising a high-density functional group, a DNA-peptide-nanomaterial composite and a preparation method therefor, and a DNA-metal nanowire and a manufacturing method therefor. The DNA-peptide composite of the present invention comprises a DNA molecule and a peptide, which comprises at least one functional group at a terminal thereof and an amino acid sequence capable of binding to the DNA molecule, wherein the peptide is bound to the DNA molecule through at least one of electrostatic interaction, intercalation, and groove binding.
Inventors:
LEE JUNG HEON (KR)
JO KYU BONG (KR)
KIM KYUNG IL (KR)
LEE SEONG HYUN (KR)
KIM SU JI (KR)
JIN XUELIN (KR)
JO KYU BONG (KR)
KIM KYUNG IL (KR)
LEE SEONG HYUN (KR)
KIM SU JI (KR)
JIN XUELIN (KR)
Application Number:
PCT/KR2017/012117
Publication Date:
May 03, 2018
Filing Date:
October 31, 2017
Export Citation:
Assignee:
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
UNIV SOGANG RES FOUNDATION (KR)
UNIV SOGANG RES FOUNDATION (KR)
International Classes:
C12Q1/68; C12N15/11
Foreign References:
| US20160137687A1 | 2016-05-19 |
Other References:
LUSCOMBE, N. M.: "An overview of the structures of protein-DNA complexes", GENOME BIOLOGY, 9 June 2000 (2000-06-09), pages 1 - 37, XP055605501
MUKHORTAVA, A.: "Efficient formation of site-specific protein-DNA hybrids using copper-free click chemistry", BIOCONJUGATE CHEMISTRY, 20 June 2016 (2016-06-20), pages 1559 - 1563, XP055605507
FENG, J.-A.: "Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactions", SCIENCE, 21 January 1994 (1994-01-21), pages 348 - 355, XP002067378, DOI: doi:10.1126/science.8278807
SCHUMACHER, M. A.: "Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices", SCIENCE, 4 November 1994 (1994-11-04), pages 763 - 770, XP055605511
KIM, K.-I.: "DNA binding peptide directed synthesis of continuous DNA nanowires for analysis of large DNA molecules by scanning electron microscope", SMALL, vol. 13, 1601926, 3 November 2016 (2016-11-03), pages 1 - 7, XP055605516
MUKHORTAVA, A.: "Efficient formation of site-specific protein-DNA hybrids using copper-free click chemistry", BIOCONJUGATE CHEMISTRY, 20 June 2016 (2016-06-20), pages 1559 - 1563, XP055605507
FENG, J.-A.: "Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactions", SCIENCE, 21 January 1994 (1994-01-21), pages 348 - 355, XP002067378, DOI: doi:10.1126/science.8278807
SCHUMACHER, M. A.: "Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices", SCIENCE, 4 November 1994 (1994-11-04), pages 763 - 770, XP055605511
KIM, K.-I.: "DNA binding peptide directed synthesis of continuous DNA nanowires for analysis of large DNA molecules by scanning electron microscope", SMALL, vol. 13, 1601926, 3 November 2016 (2016-11-03), pages 1 - 7, XP055605516
Attorney, Agent or Firm:
NAM, Gun Pil et al. (KR)
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