Title:
DNA-PK SELECTIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/036156
Kind Code:
A1
Abstract:
The present application relates to a class of DNA-PK selective inhibitors as represented by formula (II), and a preparation method therefor and the use thereof. The use comprises the use of the compound of formula (II) in the preparation of a drug for treating diseases related to DNA-PK. In the preparation process, the compound of the present invention is obtained by means of a series of reactions such as substitution, reduction, ring formation and alkylation.
Inventors:
CHEN KUNCHENG (CN)
ZHANG KAI (CN)
REN REN (CN)
LIU ZHIHUA (CN)
CHEN XI (CN)
LEI YONGKE (CN)
ZHANG KAI (CN)
REN REN (CN)
LIU ZHIHUA (CN)
CHEN XI (CN)
LEI YONGKE (CN)
Application Number:
PCT/CN2022/117405
Publication Date:
March 16, 2023
Filing Date:
September 07, 2022
Export Citation:
Assignee:
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
International Classes:
C07D519/00; A61K31/522; A61K31/5377; A61P35/00; C07D473/32; C07D498/22
Domestic Patent References:
| WO2022017368A1 | 2022-01-27 | |||
| WO2021197159A1 | 2021-10-07 | |||
| WO2019238929A1 | 2019-12-19 | |||
| WO2022177302A1 | 2022-08-25 | |||
| WO2022199547A1 | 2022-09-29 |
Foreign References:
| CN113956272A | 2022-01-21 | |||
| CN114195805A | 2022-03-18 | |||
| CN114573584A | 2022-06-03 | |||
| CN114605414A | 2022-06-10 | |||
| CN114907384A | 2022-08-16 |
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
Download PDF: