Title:
DOCETAXEL PRODRUG ANTI-TUMOR PREPARATION
Document Type and Number:
WIPO Patent Application WO/2023/109562
Kind Code:
A1
Abstract:
A docetaxel prodrug anti-tumor preparation of the present invention, relating to the field of new adjuvants and new dosage forms of pharmaceutical preparations. A docetaxel-fatty alcohol prodrug comprising different fatty alcohol side chains and different linking chains as shown in the following general formula (I) is specifically designed and synthesized, and self-assembled nanoparticles are prepared. The results show that the self-assembled nanoparticles of the docetaxel-fatty alcohol prodrug can effectively improve the curative effect of docetaxel and reduce the toxic and side effects thereof. The length of a branched chain fatty alcohol side chain, the structure (branched chain or straight chain) of the fatty alcohol side chain and the length of the linking chain can significantly influence the pharmaceutics properties, the in-vivo fate, the anti-tumor activity and the safety of the self-assembled nanoparticles of the docetaxel prodrug. Self-assembled nanoparticles of a docetaxel-branched chain fatty alcohol prodrug have higher anti-tumor activity and lower toxicity than self-assembled nanoparticles of a docetaxel-straight chain fatty alcohol prodrug.
Inventors:
SUN JIN (CN)
SUN BINGJUN (CN)
HE ZHONGGUI (CN)
DU CHAOYING (CN)
WANG DANPING (CN)
LUO CONG (CN)
LIU TIAN (CN)
DONG FUDAN (CN)
ZHANG YU (CN)
SUN BINGJUN (CN)
HE ZHONGGUI (CN)
DU CHAOYING (CN)
WANG DANPING (CN)
LUO CONG (CN)
LIU TIAN (CN)
DONG FUDAN (CN)
ZHANG YU (CN)
Application Number:
PCT/CN2022/136742
Publication Date:
June 22, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
UNIV SHENYANG PHARMACEUTICAL (CN)
International Classes:
A61K47/54; A61K31/337; A61K47/69; A61P35/00; B82Y5/00; B82Y40/00
Foreign References:
| CN105884719A | 2016-08-24 | |||
| CN112604002A | 2021-04-06 | |||
| CN113398277A | 2021-09-17 |
Attorney, Agent or Firm:
SHENYANG DONGDA INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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