Title:
DOCK1-INHIBITING COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/111252
Kind Code:
A1
Abstract:
Provided is a compound that is usable as an active ingredient of an anticancer agent. Preferably, provided is a compound that has a DOCK1-inhibiting activity and exerts an anticancer effect based on the activity. A compound represented by formula (A) or a salt thereof: in formula (A), X represents a carbon atom or a nitrogen atom; Y represents an oxygen atom, a hydroxy group or a hydrocarbon group; R1 and R2 are different and represent a hydrogen atom or a group represented by formula (A-1): (in formula (A-1), R6 represents a pyrrolidino group or a phenyl group, and n2 represents 0 or 1) ; R3 represents -CO-R7 (wherein R7 represents an alkoxy group, an alkyl group or an alkylamino group), a 1,3-oxazole group, an alkylhydroxy group, a hydrogen atom or an oxygen atom; R4 represents a hydrogen atom, an oxygen atom or a hydrocarbon group in which a hydrogen atom may be substituted; R5 represents a halogen atom, a halogenated alkyl group or a halogenated alkylthio group; and n1 represents an integer of 0-5.) ; in formula (A), a solid line on the skeleton of the compound represents a single bond, a double line consisting of a solid line and a dotted line represents a single or double bond, and tow dotted lines represent a non-bond or a double bond.
Inventors:
FUKUI YOSHINORI (JP)
URUNO TAKEHITO (JP)
KANAI MOTOMU (JP)
OISAKI KOUNOSUKE (JP)
TSUTSUMI RYOSUKE (JP)
URUNO TAKEHITO (JP)
KANAI MOTOMU (JP)
OISAKI KOUNOSUKE (JP)
TSUTSUMI RYOSUKE (JP)
Application Number:
PCT/JP2019/046862
Publication Date:
June 04, 2020
Filing Date:
November 29, 2019
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K31/40; A61K31/401; A61K31/4174; A61K31/422; A61K31/437; A61K31/4439; A61K31/444; A61P35/00; A61P35/04; A61P43/00; C07D207/36; C07D213/71; C07D213/73; C07D233/78; C07D401/10; C07D401/12; C07D405/06; C07D413/04; C07D471/04
Domestic Patent References:
| WO2018216822A1 | 2018-11-29 | |||
| WO2016136985A1 | 2016-09-01 |
Foreign References:
| US20110319459A1 | 2011-12-29 | |||
| JPS51143667A | 1976-12-10 |
Other References:
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CHEN,Y. ET AL.: "Synthesis of novel triazole and imidazole derivatives containing biphenyl", CHEMICAL RESEARCH AND APPLICATION, vol. 23, no. 3, March 2011 (2011-03-01), pages 302 - 304, XP055821841
NARDI, D.; MASSARANI, E.; CAVALLINI, G.: "a-Aminomethyl ketones, alpha-aminoethanols, and their quaternary salts, with possible pharmacological activity. Derivatives of biphenyl and diphenyl ether", BOLLETTINO CHIMICO FARMACEUTICO, vol. 102, no. 11, 1963, pages 765 - 776, XP009528516, ISSN: 0006-6648
TAJIRI,H. ET AL.: "Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of D0CK1", CELL REPORTS, vol. 19, no. 5, 2017, pages 969 - 980, XP055551141, DOI: 10.1016/j.celrep.2017.04.016
GENES DEV, vol. 28, 2014, pages 533 - 547
PROC. NATL. ACAD. SCI. USA, vol. 110, 2013, pages 7434 - 7439
CELL REPORTS, vol. 19, 2017, pages 969 - 980
NATURE, vol. 412, 2001, pages 826 - 831
EXP. CELL RES., vol. 319, 2013, pages 2343 - 2349
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 497, 2018, pages 298 - 304
CANCER RESEARCH, vol. 72, 2012, pages 2457 - 2467
NATURE REVIEWS DRUG DISCOVERY, vol. 13, 2014, pages 828 - 851
NATURE, vol. 497, 2013, pages 633 - 638
CELL RES, vol. 23, 2013, pages 982 - 983
ALLWOOD, D.M.BLAKEMORE, D.C.BROWN, A.D.LEY, S.V., J. ORG. CHEM., vol. 79, 2014, pages 328
CAS, no. 143418-49-9
HOGAN, P.J.COX, B.G., ORG. PROC. RES. DEV., vol. 13, 2009, pages 875
ZEYNIZADEH, B., J. CHEM. RES., vol. 11, 2002, pages 564
ROQUES, N, J. FLUOR. CHEM., vol. 107, 2001, pages 311
KOLCHINA, E.F.SHEKLEINA, N.V.SHELKOVNIKOV, V.V., RUSS. J. ORG. CHEM., vol. 47, 2011, pages 855
SHAVNYA, A.COFFEY, S.B.SMITH, A.C.MASCITTI, V., ORG. LETT., vol. 15, 2013, pages 6226
See also references of EP 3888651A4
CHEN,Y. ET AL.: "Synthesis of novel triazole and imidazole derivatives containing biphenyl", CHEMICAL RESEARCH AND APPLICATION, vol. 23, no. 3, March 2011 (2011-03-01), pages 302 - 304, XP055821841
NARDI, D.; MASSARANI, E.; CAVALLINI, G.: "a-Aminomethyl ketones, alpha-aminoethanols, and their quaternary salts, with possible pharmacological activity. Derivatives of biphenyl and diphenyl ether", BOLLETTINO CHIMICO FARMACEUTICO, vol. 102, no. 11, 1963, pages 765 - 776, XP009528516, ISSN: 0006-6648
TAJIRI,H. ET AL.: "Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of D0CK1", CELL REPORTS, vol. 19, no. 5, 2017, pages 969 - 980, XP055551141, DOI: 10.1016/j.celrep.2017.04.016
GENES DEV, vol. 28, 2014, pages 533 - 547
PROC. NATL. ACAD. SCI. USA, vol. 110, 2013, pages 7434 - 7439
CELL REPORTS, vol. 19, 2017, pages 969 - 980
NATURE, vol. 412, 2001, pages 826 - 831
EXP. CELL RES., vol. 319, 2013, pages 2343 - 2349
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 497, 2018, pages 298 - 304
CANCER RESEARCH, vol. 72, 2012, pages 2457 - 2467
NATURE REVIEWS DRUG DISCOVERY, vol. 13, 2014, pages 828 - 851
NATURE, vol. 497, 2013, pages 633 - 638
CELL RES, vol. 23, 2013, pages 982 - 983
ALLWOOD, D.M.BLAKEMORE, D.C.BROWN, A.D.LEY, S.V., J. ORG. CHEM., vol. 79, 2014, pages 328
CAS, no. 143418-49-9
HOGAN, P.J.COX, B.G., ORG. PROC. RES. DEV., vol. 13, 2009, pages 875
ZEYNIZADEH, B., J. CHEM. RES., vol. 11, 2002, pages 564
ROQUES, N, J. FLUOR. CHEM., vol. 107, 2001, pages 311
KOLCHINA, E.F.SHEKLEINA, N.V.SHELKOVNIKOV, V.V., RUSS. J. ORG. CHEM., vol. 47, 2011, pages 855
SHAVNYA, A.COFFEY, S.B.SMITH, A.C.MASCITTI, V., ORG. LETT., vol. 15, 2013, pages 6226
See also references of EP 3888651A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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