Title:
DOPAMINE D4 RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/1998/037893
Kind Code:
A1
Abstract:
An imide derivative represented by general formula (1) [wherein Z is represented by formula (2) (wherein B represents a carbonyl group or the like; for R?1�, R?2�, and R?3�, R?1� and R?2� combine with each other to form an optionally substituted hydrocarbon ring with R?3� representing a hydrogen atom, or alternatively R?1� and R?3� may combine with each other to form an optionally substituted hydrocarbon ring with R?2� representing a hydrogen atom; and n is 0 or 1), or a group represented by R?4�CO-NR?5�-(wherein R?4� represents an optionally substituted phenyl group or the like; and R?5� represents a hydrogen atom or a lower alkyl group); W represents an optionally substituted lower alkylene group or the like, G represents a nitrogen atom or a methine group; Ar represents an optionally substituted pyrimidyl group or the like; and Y represents a hydrogen atom or -(CH�2?)�m?- (wherein m is 1, 2 or 3) with the other end being optionally bonded to the o-position of Ar] or a pharmaceutically acceptable salt thereof is an antagonist against a dopamine D4 receptor that does not cause an extrapyramidal syndrom associated with dopamine D2 receptor antagonism and is useful as a therapeutic agent for metal disorder, e.g., schizophrenia in a negative state or the like and L-DOPA mental disorder during treatment of Parkinson's disease.
Inventors:
OHNO YUKIHIRO (JP)
KOJIMA ATSUYUKI (JP)
WAKABAYASHI JUNKO (JP)
TAGASHIRA RIE (JP)
KOJIMA ATSUYUKI (JP)
WAKABAYASHI JUNKO (JP)
TAGASHIRA RIE (JP)
Application Number:
PCT/JP1998/000744
Publication Date:
September 03, 1998
Filing Date:
February 23, 1998
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
OHNO YUKIHIRO (JP)
KOJIMA ATSUYUKI (JP)
WAKABAYASHI JUNKO (JP)
TAGASHIRA RIE (JP)
OHNO YUKIHIRO (JP)
KOJIMA ATSUYUKI (JP)
WAKABAYASHI JUNKO (JP)
TAGASHIRA RIE (JP)
International Classes:
C07D209/48; C07D209/76; C07D401/12; C07D403/12; (IPC1-7): A61K31/495
Domestic Patent References:
| WO1996014297A1 | 1996-05-17 | |||
| WO1995030659A1 | 1995-11-16 | |||
| WO1997010229A1 | 1997-03-20 | |||
| WO1997034884A1 | 1997-09-25 | |||
| WO1997038989A1 | 1997-10-23 |
Foreign References:
| JPH04230362A | 1992-08-19 | |||
| JPH04208263A | 1992-07-29 | |||
| JPS56138170A | 1981-10-28 | |||
| JPH09291033A | 1997-11-11 |
Other References:
KOEK W. et al., J. PHARMACOL. EXP. THER., (1993), 267(1), p. 181-91.
YEVICH J.P. et al., J. MED. CHEM., (1986), 29(3), p. 359-69.
BOYFIELD I. et al., BIOORG. MED. CHEM. LETT., (1996), 6(11), p. 1227-32.
MURRAY P.J. et al., BIOORG. MED. CHEM. LETT., (1995), 5(3), p. 219-22.
YEVICH J.P. et al., J. MED. CHEM., (1986), 29(3), p. 359-69.
BOYFIELD I. et al., BIOORG. MED. CHEM. LETT., (1996), 6(11), p. 1227-32.
MURRAY P.J. et al., BIOORG. MED. CHEM. LETT., (1995), 5(3), p. 219-22.
Attorney, Agent or Firm:
Nakamura, Toshio (Legal & Patent Dept., 1-98, Kasugadenaka
3-chome, Konohana-k, Osaka-shi Osaka, JP)
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