Title:
DOPAMINE-HYALURONIC ACID CONJUGATE TO BE USED AS THERAPEUTIC AGENT FOR PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/219468
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising dopamine-hyaluronic acid for treating Parkinson's disease and, particularly, to a therapeutic composition for supplying dopamine to nerve cells as a dopamine mimic. The composition has the effect of treating Parkinson's disease-induced motor disturbance by supplying dopamine to nerve cells, has low toxicity caused by auto-oxidation even if administered for a long period of time, unlike conventional dopamine and derivatives thereof supplied to the brain for treating Parkinson's disease, and provides remarkably low cell death and excellent intracellular stability.
Inventors:
LEE CHANGJOON JUSTIN (KR)
WOO DONG HO (KR)
KANG SUN-WOONG (KR)
KIM SUNPIL (KR)
KIM YE-JI (KR)
PARK KYOUNG HWAN (KR)
WOO DONG HO (KR)
KANG SUN-WOONG (KR)
KIM SUNPIL (KR)
KIM YE-JI (KR)
PARK KYOUNG HWAN (KR)
Application Number:
PCT/KR2023/006500
Publication Date:
November 16, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
A61K47/61; A61K31/137; A61P25/16
Foreign References:
| US20050153928A1 | 2005-07-14 |
Other References:
LINH T B NGUYEN; CHIA-CHEN HSU; HUA YE; ZHANFENG CUI: "Development of aninjectable hydrogel containing hyaluronic acid for neural regeneration", BIOMEDICAL MATERIALS, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 15, no. 5, 16 July 2020 (2020-07-16), GB , pages 055005, XP020356425, ISSN: 1748-605X, DOI: 10.1088/1748-605X/ab8c43
SENTHILKUMAR, K.S. SARAVANAN, K.S. CHANDRA, G. SINDHU, K.M. JAYAKRISHNAN, A. MOHANAKUMAR, K.P.: "Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism", BEHAVIOURAL BRAIN RESEARCH., ELSEVIER, AMSTERDAM., NL, vol. 184, no. 1, 18 September 2007 (2007-09-18), NL , pages 11 - 18, XP022255981, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2007.06.025
GUO MAN, MENG YINGCAI, QIN XIAOQUN, ZHOU WENHU: "Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety", CRYSTALS, vol. 11, no. 4, 30 May 2023 (2023-05-30), pages 347, XP093106302, DOI: 10.3390/cryst11040347
KIM SUNPIL, KIM YE-JI, PARK KYOUNG HWAN, HUH KANG MOO, KANG SUN-WOONG, LEE C. JUSTIN, WOO DONG HO: "Dopamine-Modified Hyaluronic Acid (DA-HA) As A Novel Dopamine-Mimetics With Minimal Autoxidation And Cytotoxicity", BIORXIV, 22 August 2022 (2022-08-22), pages 1 - 43, XP093106305, Retrieved from the Internet [retrieved on 20231128], DOI: 10.1101/2022.08.21.504712
SENTHILKUMAR, K.S. SARAVANAN, K.S. CHANDRA, G. SINDHU, K.M. JAYAKRISHNAN, A. MOHANAKUMAR, K.P.: "Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism", BEHAVIOURAL BRAIN RESEARCH., ELSEVIER, AMSTERDAM., NL, vol. 184, no. 1, 18 September 2007 (2007-09-18), NL , pages 11 - 18, XP022255981, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2007.06.025
GUO MAN, MENG YINGCAI, QIN XIAOQUN, ZHOU WENHU: "Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety", CRYSTALS, vol. 11, no. 4, 30 May 2023 (2023-05-30), pages 347, XP093106302, DOI: 10.3390/cryst11040347
KIM SUNPIL, KIM YE-JI, PARK KYOUNG HWAN, HUH KANG MOO, KANG SUN-WOONG, LEE C. JUSTIN, WOO DONG HO: "Dopamine-Modified Hyaluronic Acid (DA-HA) As A Novel Dopamine-Mimetics With Minimal Autoxidation And Cytotoxicity", BIORXIV, 22 August 2022 (2022-08-22), pages 1 - 43, XP093106305, Retrieved from the Internet
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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