DOTA COMPOUNDS AND USES THEREOF - MEMORIAL SLOAN KETTERING CANCER CENTER

Title:

DOTA COMPOUNDS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/241594

Kind Code:

A8

Abstract:

Provided herein are DOTA-containing compounds (e.g., compounds of Formula (I)) and complexes that are reactive with an enzyme activator (e.g., a peroxidase) and covalently bind a target analyte (e.g., a protein) in a catalyzed reporter deposition assaying method. The DOTA-containing compounds and complexes are advantageous over existing reporter compounds and complexes because the DOTA moiety allows detection of the reporter moiety by use of mass spectrometry imaging microscopy.

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Inventors:

OUERFELLI OUATHEK (US)
YANG GUANGBIN (US)
HOLLMANN TRAVIS (US)

Application Number:

PCT/US2019/037100

Publication Date:

January 09, 2020

Filing Date:

June 13, 2019

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Assignee:

MEMORIAL SLOAN KETTERING CANCER CENTER (US)

International Classes:

A61K31/33; C07D257/02

Attorney, Agent or Firm:

DUFFEY, Matthew, O. et al. (US)

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