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Title:
DOUBLE-HEADED PROTEASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/088270
Kind Code:
A1
Abstract:
The present invention provides a compound that is highly safe and that is useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for manufacturing the compound, and so forth. Specifically, the present invention provides: a compound represented by general formula (I) (in the formula, each of A1 and A2 independently represents an inhibitor residue possessing at least one activity that is selected from enteropeptidase inhibiting activity and strypsin inhibiting activity, and Z is a spacer that joins A1 and A2); and a pharmaceutically acceptable salt thereof.

Inventors:
YAMADA HARUKA (JP)
KOMORI KEN-ICHI (JP)
SHIRAISHI YUSUKE (JP)
UMEZAKI SATOSHI (JP)
KINOSHITA NAOYA (JP)
ITO KOJI (JP)
KANDA TOMOKO (JP)
YONEDA KENJI (JP)
TOKUNAGA YASUNORI (JP)
KIMURA TOMIO (JP)
Application Number:
JP2018/040915
Publication Date:
May 09, 2019
Filing Date:
November 02, 2018
Export Citation:
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Assignee:
UBE INDUSTRIES (JP)
International Classes:
C07C307/06; A61K31/357; A61P3/04; C07C279/18; C07D321/00
Domestic Patent References:
WO2013039187A12013-03-21
WO2006050999A22006-05-18
WO2009071601A12009-06-11
WO2015122187A12015-08-20
WO2013039187A12013-03-21
WO2014142219A12014-09-18
WO2011071048A12011-06-16
WO2012169579A12012-12-13
WO2013187533A12013-12-19
WO2015122188A12015-08-20
WO2016104630A12016-06-30
WO2016158788A12016-10-06
Foreign References:
JP2016525508A2016-08-25
JPS61143325A1986-07-01
JP2017506627A2017-03-09
JP2009526864A2009-07-23
JP2011516499A2011-05-26
JP2009537461A2009-10-29
JP2012514009A2012-06-21
JP2009524636A2009-07-02
JPS5289640A1977-07-27
Other References:
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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