Title:
DOUBLE-STRANDED RNA SPECIFICALLY INHIBITING EXPRESSION OF IL-23, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2021/201276
Kind Code:
A1
Abstract:
The present invention provides: a novel siRNA that specifically inhibits the expression of IL-23; and a pharmaceutical composition including the siRNA. More particularly, the present invention provides: a double-stranded RNA containing sense and antisense strands, wherein each strand is composed of 19-30 nucleotides and includes a base sequence of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, or SEQ ID NO: 6 and a complementary base sequence thereof; and a pharmaceutical composition including the double-stranded RNA.
Inventors:
MIWA YASUSHI (JP)
HAMAMOTO HIDETOSHI (JP)
ISHIDA TATSUHIRO (JP)
HAMAMOTO HIDETOSHI (JP)
ISHIDA TATSUHIRO (JP)
Application Number:
PCT/JP2021/014321
Publication Date:
October 07, 2021
Filing Date:
April 02, 2021
Export Citation:
Assignee:
MEDRX CO LTD (JP)
International Classes:
C12N15/113; A61K31/713; A61K47/12; A61K47/18; A61K48/00; A61P17/06; A61P43/00
Foreign References:
| JP2005530812A | 2005-10-13 |
Other References:
RASMUS O BAK;KARIN STENDERUP;CECILIA ROSADA;LINE B PETERSEN;BRIAN MOLDT;FREDERIK DAGNæS-HANSEN;MARIA JAKOBSEN;SøREN KAMP;THOMAS : "Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin", BMC DERMATOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 11, no. 1, 27 February 2011 (2011-02-27), GB , pages 5, XP021098486, ISSN: 1471-5945, DOI: 10.1186/1471-5945-11-5
J. BRUECK, S. PASCOLO, J. GEISEL: "P046: Treatment of autoimmune disease with siRNA targeting p40", EXPERIMENTAL DERMATOLOGY ONLINE, vol. 22, no. 3, 30 November 2012 (2012-11-30) - 16 March 2013 (2013-03-16), US , pages e9, XP009535948, ISSN: 1600-0625, DOI: 10.1111/exd.12072
HAWKES, J. E. ET AL.: "Psoriasis pathogenesis and the development of novel targeted immune therapies", J. ALLERGY CLIN. IMMUNOL., vol. 140, no. 3, 2017, pages 645 - 653, XP085165342, DOI: 10.1016/j.jaci.2017.07.004
SAKAMOTO, CHIKA ET AL.: "Development of novel psoriasis therapy by transdermal transdermalization of SiRNA using ionic liquid", THE 36TH ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 10 August 2020 (2020-08-10), pages 139
J. BRUECK, S. PASCOLO, J. GEISEL: "P046: Treatment of autoimmune disease with siRNA targeting p40", EXPERIMENTAL DERMATOLOGY ONLINE, vol. 22, no. 3, 30 November 2012 (2012-11-30) - 16 March 2013 (2013-03-16), US , pages e9, XP009535948, ISSN: 1600-0625, DOI: 10.1111/exd.12072
HAWKES, J. E. ET AL.: "Psoriasis pathogenesis and the development of novel targeted immune therapies", J. ALLERGY CLIN. IMMUNOL., vol. 140, no. 3, 2017, pages 645 - 653, XP085165342, DOI: 10.1016/j.jaci.2017.07.004
SAKAMOTO, CHIKA ET AL.: "Development of novel psoriasis therapy by transdermal transdermalization of SiRNA using ionic liquid", THE 36TH ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 10 August 2020 (2020-08-10), pages 139
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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