Title:
DOWNREGULATION OF CIRCULATING GHRELIN AND THERAPEUTIC APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/028518
Kind Code:
A3
Abstract:
Compositions and methods for converting ghrelin to desacyl-ghrelin include a butyrylcholinesterase (BChE) polypeptide variant. The presently-disclosed subject matter includes compositions and methods for use in directly downregulating ghrelin. In particular, certain embodiments relate to compositions and methods for hydrolyzing/deacylating ghrelin to desacyl-ghrelin and applications thereof in the treatment of disorders involving ghrelin.
Inventors:
ZHAN CHANG-GUO (US)
ZHENG FANG (US)
ZHENG FANG (US)
Application Number:
PCT/US2022/075391
Publication Date:
April 13, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
UNIV KENTUCKY RES FOUND (US)
International Classes:
A61K38/17; A61P3/04; A61P25/30; C12N9/18
Domestic Patent References:
| WO2015168207A1 | 2015-11-05 |
Foreign References:
| US20210189359A1 | 2021-06-24 | |||
| US20110098265A1 | 2011-04-28 |
Other References:
ALICIA J. DAFFERNER, SOFYA LUSHCHEKINA, PATRICK MASSON, GAOPING XIAO, LAWRENCE M. SCHOPFER, OKSANA LOCKRIDGE: "Characterization of butyrylcholinesterase in bovine serum", CHEMICO-BIOLOGICAL INTERACTIONS., ELSEVIER SCIENCE IRLAND., IR, vol. 266, 1 March 2017 (2017-03-01), IR , pages 17 - 27, XP055565084, ISSN: 0009-2797, DOI: 10.1016/j.cbi.2017.02.004
Attorney, Agent or Firm:
DECKER, Mandy Wilson et al. (US)
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