Title:
DPP-4 INHIBITOR COMPOUND, POLYMER AND PREPARATION METHOD AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2017/092083
Kind Code:
A1
Abstract:
Disclosed are a DPP-4 inhibitor compound, a polymer and a preparation method and use. The structure of said compound is X-R1-R2-Y, X and Y respectively being a group formed of a DPP-4 inhibitor or a DPP-4 inhibitor analogue containing an amino or imino group,, or being a group formed of a pharmaceutically acceptable salt or an optical isomer of the above mentioned DPP-4 inhibitor or DPP-4 inhibitor analogue containing an amino or imino group; and R1 and R2 respectively being a peptide chain fragment containing 1-6 natural or non-natural amino acid(s), or being a mercaptocarboxylic acid compound group or being a mercaptocarboxylic acid compound modified peptide chain fragment containing 1-6 natural or non-natural amino acid(s). Said DPP-4 inhibitor compound and polymer have an action curve of longer time and a lower clearance rate, and at the same time prolong the half-life period of the GLP-1 in vivo.
Inventors:
ZHANG XIAO (CN)
LI BAOQIU (CN)
ZHOU JUN (CN)
SHEN KE (CN)
YANG DONGHUI (CN)
LU YANG (CN)
LI BAOQIU (CN)
ZHOU JUN (CN)
SHEN KE (CN)
YANG DONGHUI (CN)
LU YANG (CN)
Application Number:
PCT/CN2015/098043
Publication Date:
June 08, 2017
Filing Date:
December 21, 2015
Export Citation:
Assignee:
ADLAI NORTYE BIOPHARMA CO LTD (CN)
International Classes:
C07D519/00; A61K31/4985; A61K31/506; A61K38/05; A61P3/04; A61P3/10; C07D207/16; C07D209/52; C07D401/14; C07D403/14; C07K5/062
Foreign References:
| CN101284810A | 2008-10-15 |
Other References:
LIU, MIN ET AL.: "Combination Principles and Their Application in the Design of New Drugs", CHEMICAL REAGENTS, vol. 31, no. 10, 31 October 2009 (2009-10-31), pages 795 - 797 and 850
GUO, ZONGRU: "Strategy of Molecular Drug Design: Dual-Target Drug Design", ACTAPHARMACEUTICA SINICA, vol. 44, no. 3, 31 December 2009 (2009-12-31), pages 209 - 218
WANG ZHONGLEI ET AL.: "Application of Combination Principles in the Research and Development of New Hypoglycemic Drugs", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 19, no. 4, 28 February 2013 (2013-02-28), pages 351 - 354
HAVALE, S.H. ET AL.: "Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 5, 31 January 2009 (2009-01-31), pages 1783 - 1802, XP025992047
GUO, ZONGRU: "Strategy of Molecular Drug Design: Dual-Target Drug Design", ACTAPHARMACEUTICA SINICA, vol. 44, no. 3, 31 December 2009 (2009-12-31), pages 209 - 218
WANG ZHONGLEI ET AL.: "Application of Combination Principles in the Research and Development of New Hypoglycemic Drugs", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 19, no. 4, 28 February 2013 (2013-02-28), pages 351 - 354
HAVALE, S.H. ET AL.: "Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 5, 31 January 2009 (2009-01-31), pages 1783 - 1802, XP025992047
Attorney, Agent or Firm:
GEXU INTELLECTUAL PROPERTY LAW FIRM (CN)
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