DRUG CARRIER AND PROCESS FOR PRODUCING THE SAME

Title:

DRUG CARRIER AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/2005/054302

Kind Code:

A1

Abstract:

It is intended to provide a modified water-soluble hyaluronic acid practically usable as a drug carrier and a process for producing the same. It is found out that a modified water-soluble hyaluronic acid, which is obtained by introducing a hydrazide-containing group to the carboxy group of hyaluronic acid or glucuronic acid that is a derivative thereof to an extent of 55% by mol or higher in a solvent mixture of water with a polar organic solvent, can show a retention time in the blood extended to a practically usable level which cannot be achieved by the existing modified water-soluble hyaluronic acids.

Inventors:

NAKAMURA TERUO (JP)
SIMOBOJI TSUYOSHI (JP)

Application Number:

PCT/JP2004/018060

Publication Date:

June 16, 2005

Filing Date:

December 03, 2004

Export Citation:

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)
NAKAMURA TERUO (JP)
SIMOBOJI TSUYOSHI (JP)

International Classes:

C08G63/00; (IPC1-7): C08B37/08; A61K47/48; A61L29/00

Domestic Patent References:

WO2000016818A1

2000-03-30

Foreign References:

JPH0959303A	1997-03-04
JP2002536466A	2002-10-29
JP2002519481A	2002-07-02

Other References:

POUYANI T. ET AL: "Functuicalized Derivatives of Hyaluronic Acid Oligosaccharides: Drug Carrier and Novel Biomaterials", BIOCONJYUGATE CHEM., vol. 5, 1994, pages 339 - 347, XP002274514
NAKATA T. ET AL: "Temperature- and pH-controlled Hydrogelation of Poly (ethylene glycol)-Grafted Hyaluronic Acid by Inclusion Complexation with alpha-Cyclodextrin", POLYMER JOURNAL, vol. 36, no. 4, April 2004 (2004-04-01), pages 338 - 344, XP002987150

Attorney, Agent or Firm:

Shamoto, Ichio (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)

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