Title:
DRUG CARRIER UTILIZING PROPERTY OF D-ALLOSE BEING UPTAKEN BY CANCER CELL, DRUG DELIVERY METHOD, AND COMPOSITION FOR TREATING RENAL CELL CARCINOMA
Document Type and Number:
WIPO Patent Application WO/2020/189000
Kind Code:
A1
Abstract:
Problem: to provide a composition for treating renal cell carcinoma and to provide a composition or method for enhancing drug uptake by renal cell carcinoma cells. Constitution: a composition for treating renal cell carcinoma, the composition comprising D-allose, or a composition or method for enhancing drug uptake by renal cell carcinoma cells, the composition comprising D-allose. The composition is a pharmaceutical composition for administration, in a human or nonhuman animal, in an effective amount to a patient requiring the treatment of renal cell carcinoma.
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Inventors:
TAOKA RIKIYA (JP)
KAKEHI YOSHIYUKI (JP)
SUGIMOTO MIKIO (JP)
ZHANG XIA (JP)
MATSUOKA YUKI (JP)
IZUMORI KEN (JP)
YOSHIHARA AKIHIDE (JP)
KAKEHI YOSHIYUKI (JP)
SUGIMOTO MIKIO (JP)
ZHANG XIA (JP)
MATSUOKA YUKI (JP)
IZUMORI KEN (JP)
YOSHIHARA AKIHIDE (JP)
Application Number:
PCT/JP2020/002292
Publication Date:
September 24, 2020
Filing Date:
January 23, 2020
Export Citation:
Assignee:
UNIV KAGAWA NAT UNIV CORP (JP)
International Classes:
A61K31/047; A61K31/133; A61K31/191; A61K31/7004; A61K45/00; A61K47/26; A61K47/55; A61P13/12; A61P35/00; A61P43/00
Domestic Patent References:
| WO2016152293A1 | 2016-09-29 | |||
| WO2003097820A1 | 2003-11-27 |
Foreign References:
| JP2015155392A | 2015-08-27 | |||
| JPS5330976B1 | 1978-08-30 | |||
| JP2004298106A | 2004-10-28 |
Other References:
NOBUYASU SUGANUMA, SEGADE FERNANDO, MATSUZU KENICHI, BOWDEN DONALD W.: "Differential expression of facilitative glucose transporters in normal and tumour kidney tissues", BJU INT, vol. 99, no. 5, 8 April 2007 (2007-04-08) - May 2007 (2007-05-01), pages 1143 - 1149, XP055741384
YUKI MIYAWAKI, UEKI MASAAKI, UENO MASAKI, ASAGA TAKEHIKO, TOKUDA MASAAKI, SHIRAKAMI GOTARO: "D-allose ameliorates cisplatin-induced nephrotoxicity in mice", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE., vol. 228, no. 3, November 2012 (2012-11-01), pages 215 - 221, XP055741416
KLEINZELLER A; MCAVOY E M; MCKIBBIN R D: "Active renal hexose transport. Structual requirements", BBA - BIOMEMBRANES, vol. 600, no. 2, 4 August 1980 (1980-08-04), pages 513 - 529, XP023364981
YUKI MATSUOKA, TOSHIYA TAOKA, KASUMI ZHANG, MIKIFUMI SUGIMOTO, YOSHIYUKI KAKE: "YU-2. Growth Inhibitory Effect of Rare Sugar D-allose on Renal Cell Carcinoma", THE NISHINIHON JOURNAL OF UROLOGY, vol. 81, no. Suppl. 1, 20 October 2019 (2019-10-20), JP, pages 135, XP009530421, ISSN: 0029-0726
TOYOHARA, J. ET AL.: "Searching for diagnostic properties of novel fluorine-18-labeled D-allose", ANN NUCL MED, vol. 33, no. 11, 30 August 2019 (2019-08-30), pages 855 - 865, XP036916846, DOI: 10.1007/s12149-019-01398-x
J. FERMENT. BIOENG., vol. 84, 1997, pages 319
See also references of EP 3943078A4
YUKI MIYAWAKI, UEKI MASAAKI, UENO MASAKI, ASAGA TAKEHIKO, TOKUDA MASAAKI, SHIRAKAMI GOTARO: "D-allose ameliorates cisplatin-induced nephrotoxicity in mice", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE., vol. 228, no. 3, November 2012 (2012-11-01), pages 215 - 221, XP055741416
KLEINZELLER A; MCAVOY E M; MCKIBBIN R D: "Active renal hexose transport. Structual requirements", BBA - BIOMEMBRANES, vol. 600, no. 2, 4 August 1980 (1980-08-04), pages 513 - 529, XP023364981
YUKI MATSUOKA, TOSHIYA TAOKA, KASUMI ZHANG, MIKIFUMI SUGIMOTO, YOSHIYUKI KAKE: "YU-2. Growth Inhibitory Effect of Rare Sugar D-allose on Renal Cell Carcinoma", THE NISHINIHON JOURNAL OF UROLOGY, vol. 81, no. Suppl. 1, 20 October 2019 (2019-10-20), JP, pages 135, XP009530421, ISSN: 0029-0726
TOYOHARA, J. ET AL.: "Searching for diagnostic properties of novel fluorine-18-labeled D-allose", ANN NUCL MED, vol. 33, no. 11, 30 August 2019 (2019-08-30), pages 855 - 865, XP036916846, DOI: 10.1007/s12149-019-01398-x
J. FERMENT. BIOENG., vol. 84, 1997, pages 319
See also references of EP 3943078A4
Attorney, Agent or Firm:
SUDO, Akinobu et al. (JP)
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