Title:
DRUG COMPLEX
Document Type and Number:
WIPO Patent Application WO/2016/208761
Kind Code:
A1
Abstract:
[Problem] To provide a drug delivery system that can deliver a drug into a cell expressing a VEGF receptor. [Solution] Provided is a VEGF binding peptide-drug complex which is incorporated into VEGF receptor-expressing cells by VEGF receptor endocytosis, by binding a drug to the C-terminal amino acid or the N-terminal amino acid of a VEGF binding peptide having a helix-loop-helix structure comprising an A block located on the N-terminal side comprising a peptide that forms an α-helix structure, a C block located on the C-terminal side comprising a peptide that forms an α-helix structure, and a B block comprising a peptide that connects the A block and C block by covalent bonds.
Inventors:
FUJII IKUO (JP)
Application Number:
PCT/JP2016/068934
Publication Date:
December 29, 2016
Filing Date:
June 25, 2016
Export Citation:
Assignee:
UNIV OSAKA PREFECT PUBLIC CORP (JP)
International Classes:
A61K47/42; A61K47/48; A61P35/00; C07K2/00; C07K14/00
Foreign References:
| JP2014047156A | 2014-03-17 | |||
| JP2011231085A | 2011-11-17 |
Other References:
TAHAHASHI KENTARO ET AL.: "Chemical Synthesis of Head-to-Tail Cyclized Anti-VEGF Microantibody", PEPT. SCI., vol. 14, 20 March 2015 (2015-03-20), pages 143 - 144, XP009505635
KUNIO FUJII: "Beyond Antibodies: Directed evolution of molecular-Targeting peptides in phage-displayed libraries of conformationally constrained Peptides", DRUG DELIVERY SYSTEM, vol. 26, no. 6, 2011, pages 593 - 603, XP002758789, DOI: doi:10.2745/dds.26.593
See also references of EP 3338805A4
KUNIO FUJII: "Beyond Antibodies: Directed evolution of molecular-Targeting peptides in phage-displayed libraries of conformationally constrained Peptides", DRUG DELIVERY SYSTEM, vol. 26, no. 6, 2011, pages 593 - 603, XP002758789, DOI: doi:10.2745/dds.26.593
See also references of EP 3338805A4
Attorney, Agent or Firm:
SHIMURA HISASHI (JP)
Shoji Shimura (JP)
Shoji Shimura (JP)
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