DRUG COMPOSITION FOR PARENTERAL ADMINISTRATION

WIPO Patent Application WO/2018/003857

A1

Provided is a curcumine preparation which is highly water soluble, is capable of maintaining a sufficiently high blood concentration of free curcumine and capable of effectively obtaining the pharmacological effect of curcumine by parenteral administration, and which is highly safe. The pharmaceutical composition for parenteral administration comprises a water-soluble substance conjugate of curcumine as the active ingredient.

KAKEYA HIDEAKI (JP)
KANAI MASASHI (JP)
TAKAHASHI NOBUAKI (JP)
HASHIMOTO TADASHI (JP)
IMAIZUMI ATSUSHI (JP)
OZAWA HIROMI (JP)

PCT/JP2017/023753

January 04, 2018

June 28, 2017

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THERABIOPHARMA INC (JP)
UNIV KYOTO (JP)

A61K31/7028; A61K31/12; A61K31/185; A61K31/223; A61K38/00; A61P3/06; A61P9/00; A61P25/28; A61P29/00; A61P35/00; A61P37/08

US20100316631A1	2010-12-16
JP2015054846A	2015-03-23
JP2007319030A	2007-12-13
JP2009529506A	2009-08-20

THANGAVEL, A ET AL.: "Redox nanoparticles inhibit curcumin oxidative degradation and enhance its therapeutic effect on prostate cancer", J. CONTROLLED RELEASE, vol. 209, 22 April 2015 (2015-04-22), pages 110 - 119, XP029173931
SAHU, A ET AL.: "Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells", ACTA BIOMATERIALIA, vol. 4, no. 6, 11 May 2008 (2008-05-11), pages 1752 - 1761, XP025535837
See also references of EP 3479828A4

THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)

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