Title:
DRUG COMPOUND AND PURIFICATION METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/025863
Kind Code:
A3
Abstract:
The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.
Inventors:
JOSHI-HANGAL RAJASHREE (US)
DAVAR NIPUN (US)
PRIEBE STEPHEN (US)
DAVAR NIPUN (US)
PRIEBE STEPHEN (US)
Application Number:
PCT/IB2018/000992
Publication Date:
March 14, 2019
Filing Date:
August 02, 2018
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
A61K31/7084; A61K9/19; F26B5/06
Domestic Patent References:
| WO2013033176A1 | 2013-03-07 |
Foreign References:
| US20170000738A1 | 2017-01-05 |
Attorney, Agent or Firm:
SHUSAKU YAMAMOTO (JP)
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