Title:
DRUG CONJUGATE OF GLUCOCORTICOID RECEPTOR AGONIST, AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2022/166779
Kind Code:
A1
Abstract:
A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.
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Inventors:
ZHU LINGJIAN (CN)
HONG MIN (CN)
TANG MANPING (CN)
SU LU (CN)
DENG MENGDIE (CN)
ZHANG JINGYANG (CN)
REN WENMING (CN)
LIN KAN (CN)
HUANG JIAN (CN)
LIAO CHENG (CN)
ZHANG LIANSHAN (CN)
HONG MIN (CN)
TANG MANPING (CN)
SU LU (CN)
DENG MENGDIE (CN)
ZHANG JINGYANG (CN)
REN WENMING (CN)
LIN KAN (CN)
HUANG JIAN (CN)
LIAO CHENG (CN)
ZHANG LIANSHAN (CN)
Application Number:
PCT/CN2022/074455
Publication Date:
August 11, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
SHANGHAI SENHUI MEDICINE CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
International Classes:
C07J71/00; A61K31/58; A61K47/68; A61P37/00; C07K16/24
Domestic Patent References:
| WO2005028495A1 | 2005-03-31 | |||
| WO2017210471A1 | 2017-12-07 | |||
| WO2019106609A1 | 2019-06-06 | |||
| WO2013087912A1 | 2013-06-20 | |||
| WO2014152247A1 | 2014-09-25 | |||
| WO2015073884A2 | 2015-05-21 |
Foreign References:
| CN109476699A | 2019-03-15 | |||
| CN111465399A | 2020-07-28 | |||
| CN111417410A | 2020-07-14 | |||
| CN102015750A | 2011-04-13 | |||
| CN110291097A | 2019-09-27 | |||
| CN112004557A | 2020-11-27 | |||
| US20050238649A1 | 2005-10-27 | |||
| US5208020A | 1993-05-04 |
Other References:
CHARI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 127 - 131
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT, E. A ET AL., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST, 1991
QUEEN ET AL., PROC., NATL. ACAD. SCI. USA, vol. 88, 1991, pages 2869
JONES ET AL., NATURE, vol. 321, 1986, pages 522
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYEN ET AL., SCIENCE, vol. 242, 1988, pages 1534 - 426
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL, vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL, vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
KABAT E.A ET AL., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST, 1991
KABAT ET AL.: "Public Health Service", 1991, NATIONAL INSTITUTES OF HEALTH, article "Sequences of Proteins of Immunological Interest"
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P, IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P ET AL., DEV. COMP. IMMUNOL, vol. 27, 2003, pages 55 - 77
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
IMMUNOGLOBULIN JOURNAL, 2001, ISBN: 012441351
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis"
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT, E. A ET AL., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST, 1991
QUEEN ET AL., PROC., NATL. ACAD. SCI. USA, vol. 88, 1991, pages 2869
JONES ET AL., NATURE, vol. 321, 1986, pages 522
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
VERHOEYEN ET AL., SCIENCE, vol. 242, 1988, pages 1534 - 426
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG, vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL, vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL, vol. 293, 1999, pages 41 - 56
ROOVERS ET AL., CANCER IMMUNOL, 2001
KABAT E.A ET AL., SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST, 1991
KABAT ET AL.: "Public Health Service", 1991, NATIONAL INSTITUTES OF HEALTH, article "Sequences of Proteins of Immunological Interest"
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P, IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P ET AL., DEV. COMP. IMMUNOL, vol. 27, 2003, pages 55 - 77
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
IMMUNOGLOBULIN JOURNAL, 2001, ISBN: 012441351
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis"
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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