Title:
DRUG DELIVERY VIA THERAPEUTIC HYDROGELS
Document Type and Number:
WIPO Patent Application WO1998046287
Kind Code:
A3
Abstract:
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
Inventors:
DICOSMO FRANK (CA)
DITIZIO VALERIO (CA)
DITIZIO VALERIO (CA)
Application Number:
PCT/CA1998/000351
Publication Date:
February 11, 1999
Filing Date:
April 15, 1998
Export Citation:
Assignee:
UNIV TORONTO (CA)
DICOSMO FRANK (CA)
DITIZIO VALERIO (CA)
DICOSMO FRANK (CA)
DITIZIO VALERIO (CA)
International Classes:
A61L27/00; A61K9/127; A61L27/34; A61L27/52; A61L27/54; A61L29/00; A61L29/08; A61L29/14; A61L29/16; (IPC1-7): A61L27/00
Domestic Patent References:
| WO1991009616A1 | 1991-07-11 |
Foreign References:
| US5575815A | 1996-11-19 | |||
| CA2181390A1 | 1997-01-19 | |||
| US4749585A | 1988-06-07 |
Other References:
"Liposomal-Hydrogel Delivery of Ciprofloxacin at Catheter Surfaces", M.W. MITTELMAN ET AL, 37th INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, TORONTO, CANADA, SEPTEMBER 28-OCTOBER 1, 1997, Abstracts 37 (0), page 325
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