Title:
DRUG KIT AND METHOD FOR REBUILDING DAMAGED NEURAL PATHWAYS
Document Type and Number:
WIPO Patent Application WO/2022/234843
Kind Code:
A1
Abstract:
The present invention provides a drug kit for rebuilding a damaged neural pathway, wherein the drug kit comprises a first formulation comprising axonal elongation-inducing protein, nucleic acid encoding said protein, or a vector that expressibly contains DNA encoding said protein. The present invention also provides a method for rebuilding a damaged neural pathway in a patient, the method comprising the administration of the first formulation of this drug kit.
Inventors:
TAKAHASHI JUN (JP)
TSUCHIMOCHI RYOSUKE (JP)
TSUCHIMOCHI RYOSUKE (JP)
Application Number:
PCT/JP2022/019484
Publication Date:
November 10, 2022
Filing Date:
May 02, 2022
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K38/02; A61K35/30; A61K35/545; A61K48/00; A61L27/38; A61P25/28
Other References:
PŁATEK RAFAŁ, GRYCZ KAMIL, WIĘCKOWSKA ANGELIKA, CZARKOWSKA-BAUCH JULITA, SKUP MAŁGORZATA: "L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection", JOURNAL OF NEUROTRAUMA., M.A. LIEBERT, NEW YORK, NY., US, vol. 37, no. 3, 1 February 2020 (2020-02-01), US , pages 534 - 554, XP093000789, ISSN: 0897-7151, DOI: 10.1089/neu.2018.6103
CHEN JIAN, WU JUNFANG, APOSTOLOVA IVAYLA, SKUP MALGORZATA, IRINTCHEV ANDREY, KÜGLER SEBASTIAN, SCHACHNER MELITTA: "Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury", BRAIN, OXFORD UNIVERSITY PRESS, GB, vol. 130, no. 4, 1 April 2007 (2007-04-01), GB , pages 954 - 969, XP093000787, ISSN: 0006-8950, DOI: 10.1093/brain/awm049
SERAFINI T, ET AL.: "THE NETRINS DEFINE A FAMILY OF AXON OUTGROWTH-PROMOTING PROTEINS HOMOLOGOUS TO C. ELEGANS UNC-6", CELL, ELSEVIER, AMSTERDAM NL, vol. 78, no. 03, 12 August 1994 (1994-08-12), Amsterdam NL , pages 409 - 424, XP000941993, ISSN: 0092-8674, DOI: 10.1016/0092-8674(94)90420-0
OKUBO TOSHIKI, IWANAMI AKIO, KOHYAMA JUN, ITAKURA GO, KAWABATA SOYA, NISHIYAMA YUICHIRO, SUGAI KEIKO, OZAKI MASAHIRO, IIDA TSUYOSH: "Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 7, no. 4, 1 October 2016 (2016-10-01), United States , pages 649 - 663, XP093000784, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2016.08.015
NAGOSHI NARIHITO, OKANO HIDEYUKI, NAKAMURA MASAYA: "Regenerative therapy for spinal cord injury using iPSC technology", INFLAMMATION AND REGENERATION, vol. 40, no. 1, 1 December 2020 (2020-12-01), XP093000783, DOI: 10.1186/s41232-020-00149-0
KAJIKAWA KEITA, IMAIZUMI KENT, SHINOZAKI MUNEHISA, SHIBATA SHINSUKE, SHINDO TOMOKO, KITAGAWA TAKAHIRO, SHIBATA REO, KAMATA YASUHIR: "Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells", MOLECULAR BRAIN, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP093000781, DOI: 10.1186/s13041-020-00662-w
TSUCHIMOCHI, RYOSUKE ET AL.: "O8-5 Promotion of cell transplantation effect by forced expression of axon guidance factor in the host brain", THE 21ST ANNUAL MEETING OF THE JAPAN SOCIETY OF MOLECULAR NEUROSURGERY; SEPTEMBER 24-25, 2021, JAPAN SOCIETY OF MOLECULAR NEUROSURGERY, JP, 24 September 2021 (2021-09-24) - 25 September 2021 (2021-09-25), JP, pages 68, XP009541025
CHEN JIAN, WU JUNFANG, APOSTOLOVA IVAYLA, SKUP MALGORZATA, IRINTCHEV ANDREY, KÜGLER SEBASTIAN, SCHACHNER MELITTA: "Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury", BRAIN, OXFORD UNIVERSITY PRESS, GB, vol. 130, no. 4, 1 April 2007 (2007-04-01), GB , pages 954 - 969, XP093000787, ISSN: 0006-8950, DOI: 10.1093/brain/awm049
SERAFINI T, ET AL.: "THE NETRINS DEFINE A FAMILY OF AXON OUTGROWTH-PROMOTING PROTEINS HOMOLOGOUS TO C. ELEGANS UNC-6", CELL, ELSEVIER, AMSTERDAM NL, vol. 78, no. 03, 12 August 1994 (1994-08-12), Amsterdam NL , pages 409 - 424, XP000941993, ISSN: 0092-8674, DOI: 10.1016/0092-8674(94)90420-0
OKUBO TOSHIKI, IWANAMI AKIO, KOHYAMA JUN, ITAKURA GO, KAWABATA SOYA, NISHIYAMA YUICHIRO, SUGAI KEIKO, OZAKI MASAHIRO, IIDA TSUYOSH: "Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 7, no. 4, 1 October 2016 (2016-10-01), United States , pages 649 - 663, XP093000784, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2016.08.015
NAGOSHI NARIHITO, OKANO HIDEYUKI, NAKAMURA MASAYA: "Regenerative therapy for spinal cord injury using iPSC technology", INFLAMMATION AND REGENERATION, vol. 40, no. 1, 1 December 2020 (2020-12-01), XP093000783, DOI: 10.1186/s41232-020-00149-0
KAJIKAWA KEITA, IMAIZUMI KENT, SHINOZAKI MUNEHISA, SHIBATA SHINSUKE, SHINDO TOMOKO, KITAGAWA TAKAHIRO, SHIBATA REO, KAMATA YASUHIR: "Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells", MOLECULAR BRAIN, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP093000781, DOI: 10.1186/s13041-020-00662-w
TSUCHIMOCHI, RYOSUKE ET AL.: "O8-5 Promotion of cell transplantation effect by forced expression of axon guidance factor in the host brain", THE 21ST ANNUAL MEETING OF THE JAPAN SOCIETY OF MOLECULAR NEUROSURGERY; SEPTEMBER 24-25, 2021, JAPAN SOCIETY OF MOLECULAR NEUROSURGERY, JP, 24 September 2021 (2021-09-24) - 25 September 2021 (2021-09-25), JP, pages 68, XP009541025
Attorney, Agent or Firm:
MURAOKA, Koichiro et al. (JP)
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