DRUG-LOADED BALLOON AND PREPARATION METHOD THEREFOR

Title:

DRUG-LOADED BALLOON AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2024/060540

Kind Code:

A1

Abstract:

Provided are a drug-loaded balloon and a preparation method therefor. The drug-loaded balloon comprises a balloon body and drug-loaded coatings. The drug-loaded coatings comprise a first drug-loaded coating comprising at least two controllable sustained-release drugs with different drug release kinetics; and a second drug-loaded coating consisting of active drugs in a free non-binding form, which are dispersed among the controllable sustained-release drugs in the first drug-loaded coating and couple the controllable sustained-release drugs to the balloon body. The first drug-loaded coating and the second drug-loaded coating are both non-hydrophilic in composition. The drug-loaded balloon can provide a sufficient initial load drug dose to a site of lesion, and the plurality of controllable sustained-release drugs have different drug release kinetics, such that explosive release and vanishment can be avoided. Moreover, the drug release rate can be adjusted by means of different combination modes, such that the drug-loaded balloon can provide a bioactive drug for a site under treatment according to different stages of a vascular restenosis cascade reaction, thereby providing a controllable long-acting treatment drug for the site of lesion, and improving the overall vascular drug release rate.

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Inventors:

WANG LIWEI (CN)
HUANG JUNYI (CN)
ZHANG ZHIJUN (CN)
LI BIN (CN)

Application Number:

PCT/CN2023/082108

Publication Date:

March 28, 2024

Filing Date:

March 17, 2023

Export Citation:

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Assignee:

BROSMED MEDICAL CO LTD (CN)

International Classes:

A61L29/08; A61L29/14; A61L29/16

Foreign References:

CN115501395A	2022-12-23
CN114870096A	2022-08-09
CN108465129A	2018-08-31
CN1883720A	2006-12-27
CN104841060A	2015-08-19
CN204182007U	2015-03-04
CN104511084A	2015-04-15
CN110882473A	2020-03-17
US20160250452A1	2016-09-01

Other References:

LI-FU MIAO, YANG JING, HUANG CHAO-LIAN, SONG CUN-XIAN, ZENG YU-JIE, CHEN LIAN-FEN: "Rapamycin-loaded Poly(lactic-co-glycolic) Acid Nanoparticles for Intraarterial Local Drug Delivery:Preparation,Characterization,and in vitro/in vivo Release ", ACTA ACADEMIAE MEDICINAE SINICAE, vol. 30, no. 4, 30 August 2008 (2008-08-30), pages 491 - 497, XP093149480

Attorney, Agent or Firm:

SCIHEAD IP LAW FIRM (CN)

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