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Title:
DRUG-LOADED NANOCOMPOSITE FIBER MEMBRANE SYSTEM, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/186714
Kind Code:
A1
Abstract:
A drug-loaded nanocomposite fiber membrane system, a preparation method therefor and use thereof. The drug-loaded nanocomposite fiber membrane system comprises a first nanofiber layer, a second nanofiber layer and a third nanofiber layer. The first nanofiber layer comprises a polylactic acid-glycolic acid copolymer, polydioxanone and a drug. The second nanofiber layer comprises a polylactic acid-glycolic acid copolymer, polyglycolic acid and a drug. The third nanofiber layer comprises a polylactic acid-glycolic acid copolymer, polyethylene glycol and a drug. The preparation method therefor comprises: respectively dissolving and mixing the polymer material and drug contained in each nanofiber layer to obtain three mixed solutions, and sequentially subjecting the three mixed solutions to electrospinning. Said system is a complete drug sustained-release system lasting from zero days to two and a half months, achieving multi-gradient and multi-stage long-acting drug release.

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Inventors:
HAN ZHICHAO (CN)
XU SHANSHAN (CN)
WU JIAEN (CN)
WANG LAN (CN)
Application Number:
PCT/CN2019/106836
Publication Date:
September 24, 2020
Filing Date:
September 20, 2019
Export Citation:
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Assignee:
SHENZHEN GUANGYUAN BIOMATERIAL CO LTD (CN)
International Classes:
A61K31/513; A61K9/70; A61K31/704; A61K33/243; A61K47/32; A61K47/34; A61P35/00; D01D5/00; D04H1/728
Foreign References:
CN109908108A2019-06-21
CN107625995A2018-01-26
Other References:
CHEN, SHIXUAN ET AL.: "Emerging Roles of Electrospun Nanofibers in Cancer Research", ADVANCED HEALTHCARE MATERIALS, vol. 6, no. 7, 6 December 2017 (2017-12-06), XP055734173, ISSN: 2192-2659, DOI: 20191220212152Y
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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