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Title:
DRUG FOR PREVENTION OR TREATMENT OF SPINOCEREBELLAR DEGENERATION
Document Type and Number:
WIPO Patent Application WO/2015/053402
Kind Code:
A1
Abstract:
In order to provide a compound capable of treating or preventing spinocerebellar degeneration, analysis was undertaken using screening, etc., using a spinocerebellar degeneration type 1 (SCA1) fly model. As a result, RPA1, PNKP, XRCC3, XRCC4, CCNH, POLE, POLH, and PER1 were identified as proteins that promote recovery from spinocerebellar degeneration. On the other hand, CHK1, LIG3, FEN1, LIG1, ERCC5, XAB2, ERCC2, DMC1, RECQL5, MUS81, EME1, SPO11, and BLM were identified as proteins that exacerbate said condition. In addition, it was clarified that the activity of these proteins was suppressed and the condition occurred as a result of ATXN1, a cause of SCA1, bonding with RPA1, BRCA1, and BRCA2.

Inventors:
OKAZAWA HITOSHI (JP)
Application Number:
PCT/JP2014/077258
Publication Date:
April 16, 2015
Filing Date:
October 10, 2014
Export Citation:
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Assignee:
NAT UNIV CORP TOKYO MED & DENT (JP)
International Classes:
A61K38/00; A61K31/4535; A61K31/4545; A61K31/4709; A61K31/519; A61K31/5377; A61K31/55; A61K31/553; A61K45/00; A61K48/00; A61P25/00; G01N33/15; G01N33/50; C12N15/09; C12Q1/25; C12Q1/48; C12Q1/68
Domestic Patent References:
WO2014151529A12014-09-25
WO2010118390A12010-10-14
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JP2008512344A2008-04-24
JP2011254701A2011-12-22
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See also references of EP 3056210A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
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