Title:
DRUG FOR REMEDY OR TREATMENT OF WOUND
Document Type and Number:
WIPO Patent Application WO/2005/112948
Kind Code:
A1
Abstract:
The epidermis-regenerating effect of various chitin derivatives is revealed and a drug for the remedy or treatment of wounds which is effectively usable clinically is provided. It has become obvious that N-acetyl-D-glucosamine has the effect of accelerating the proliferation of epidermal keratinocytes. Thus, an epidermal kerationocyte growth accelerator containing N-acetyl-D-glcosamine is provided. Also provided are a regeneration accelerator and a protective agent for the epithelium, skin, or corium.
Inventors:
MINAMI SABURO (JP)
OKAMOTO YOSHIHARU (JP)
OKAMOTO YOSHIHARU (JP)
Application Number:
PCT/JP2005/008884
Publication Date:
December 01, 2005
Filing Date:
May 16, 2005
Export Citation:
Assignee:
UNIV TOTTORI (JP)
MINAMI SABURO (JP)
OKAMOTO YOSHIHARU (JP)
MINAMI SABURO (JP)
OKAMOTO YOSHIHARU (JP)
International Classes:
A61K31/7008; A61K31/722; A61P17/00; A61P17/02; (IPC1-7): A61K31/7008; A61K31/722; A61P17/00; A61P17/02
Domestic Patent References:
| WO2003015797A1 | 2003-02-27 | |||
| WO2003026677A1 | 2003-04-03 |
Foreign References:
| JP2004346041A | 2004-12-09 | |||
| JPH10175857A | 1998-06-30 | |||
| JP2002534369A | 2002-10-15 | |||
| JPS63501077A | 1988-04-21 | |||
| US3232836A | 1966-02-01 | |||
| JP2003507400A | 2003-02-25 | |||
| JP2001002551A | 2001-01-09 | |||
| JP2004083539A | 2004-03-18 | |||
| JP2004107265A | 2004-04-08 | |||
| JP2003183296A | 2003-07-03 | |||
| JP2004002369A | 2004-01-08 | |||
| JPH10287570A | 1998-10-27 |
Other References:
OKAMOTO Y. ET AL: "Toshitsu Kagaku ni okeru Post Genome Kenkyu -Kinosei Kurikaeshi Tosa ni Kiso to Oyo-Chitin/Chitosan to Soho Chiyu", NIPPON NOGEI KAGAKU KAISHI, vol. 78, no. 9, 1 September 2004 (2004-09-01), pages 847 - 850, XP002997083
YANO H. ET AL: "Effects of N-Acetyl-D-Glucosamine on Wound Healing in Rats", MIE MEDICAL JOURNAL, vol. XXXV, no. 1, 1985, pages 53 - 56, XP002997084
DATABASE CA [online] YAKOVLEVA L.V. ET AL: "Relation between antialternative and antiproliferative effects of indomethacin, voltaren, piroxicam and D-glucosamine", XP002997085, Database accession no. 109:16725
HOWLING G.I. ET AL: "The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro", BIOMATERIALS, vol. 22, 2001, pages 2959 - 2966, XP004301374
OKAMOTO Y. ET AL: "Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium", BIOMATERIALS, vol. 23, 2002, pages 1975 - 1979, XP004345242
MORI T. ET AL: "Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro", BIOMATERIALS, vol. 18, 1997, pages 947 - 951, XP004074547
SCHMIDT R.J. ET AL: "Biocompatibility of wound management products: the effect of various monosaccharides on L929 and 2002 fibroblast cells in culture", J.PHARM.PHARMACOL., vol. 41, 1989, pages 781 - 784, XP002997086
MINAMI S. ET AL: "Chitin-shitsu no Sosho Chiyu Sokushin Kiko", CHITIN AND CHITOSAN RESEARCH, vol. 5, no. 1, 1999, pages 1 - 13, XP002997087
NAKADE T. ET AL: "Tennen Tato beta-Chitin no Inu no Sosho Chiyu Sokushin Koka", JOURNAL OF THE JAPAN VETERINARY MEDICAL ASSOCIATION, vol. 49, no. 4, 1996, pages 249 - 252, XP002997088
See also references of EP 1749532A4
YANO H. ET AL: "Effects of N-Acetyl-D-Glucosamine on Wound Healing in Rats", MIE MEDICAL JOURNAL, vol. XXXV, no. 1, 1985, pages 53 - 56, XP002997084
DATABASE CA [online] YAKOVLEVA L.V. ET AL: "Relation between antialternative and antiproliferative effects of indomethacin, voltaren, piroxicam and D-glucosamine", XP002997085, Database accession no. 109:16725
HOWLING G.I. ET AL: "The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro", BIOMATERIALS, vol. 22, 2001, pages 2959 - 2966, XP004301374
OKAMOTO Y. ET AL: "Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium", BIOMATERIALS, vol. 23, 2002, pages 1975 - 1979, XP004345242
MORI T. ET AL: "Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro", BIOMATERIALS, vol. 18, 1997, pages 947 - 951, XP004074547
SCHMIDT R.J. ET AL: "Biocompatibility of wound management products: the effect of various monosaccharides on L929 and 2002 fibroblast cells in culture", J.PHARM.PHARMACOL., vol. 41, 1989, pages 781 - 784, XP002997086
MINAMI S. ET AL: "Chitin-shitsu no Sosho Chiyu Sokushin Kiko", CHITIN AND CHITOSAN RESEARCH, vol. 5, no. 1, 1999, pages 1 - 13, XP002997087
NAKADE T. ET AL: "Tennen Tato beta-Chitin no Inu no Sosho Chiyu Sokushin Koka", JOURNAL OF THE JAPAN VETERINARY MEDICAL ASSOCIATION, vol. 49, no. 4, 1996, pages 249 - 252, XP002997088
See also references of EP 1749532A4
Attorney, Agent or Firm:
Suzuye, Takehiko c/o SUZUYE & SUZUYE (1-12-9 Toranomo, Minato-ku Tokyo 01, JP)
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