Title:
DRUG FOR RETINAL DEGENERATIVE DISEASE ASSOCIATED WITH PHOTORECEPTOR DEGENERATION
Document Type and Number:
WIPO Patent Application WO/2019/009265
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a medicine with which it is possible to simply treat and/or prevent retinal degenerative diseases associated with photoreceptor degeneration, including retinitis pigmentosa. The solution is to provide an agent for treating and/or preventing retinal degenerative diseases associated with photoreceptor degeneration, the agent being characterized by containing a compound having a retinoic acid receptor agonistic action (such as tamibarotene, tamibarotene methyl ester, tamibarotene ethyl ester, tazarotene, tazarotenic acid, adapalene, palovalotene, retinol, isotretinoin, alitretinoin, etretinate, acitretin, and bexarotene) or a salt thereof.
Inventors:
TSUJI NAOKI (JP)
UENO MASUMI (JP)
UENO MASUMI (JP)
Application Number:
PCT/JP2018/025122
Publication Date:
January 10, 2019
Filing Date:
July 03, 2018
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K45/00; A01K67/027; A61K31/07; A61K31/192; A61K31/203; A61K31/232; A61K31/415; A61K31/4436; A61K31/455; A61K35/545; A61L27/36; A61L27/38; A61P27/02; A61P43/00; C12N5/073; C12N5/074; C12N15/90; G01N33/15; G01N33/50
Domestic Patent References:
| WO2007037188A1 | 2007-04-05 | |||
| WO1998045331A2 | 1998-10-15 | |||
| WO1998018480A1 | 1998-05-07 |
Foreign References:
| JP2007513161A | 2007-05-24 | |||
| JP2007528851A | 2007-10-18 | |||
| JP2014517077A | 2014-07-17 | |||
| US6344463B1 | 2002-02-05 |
Other References:
TANG, S. ET AL.: "Experimental studies of effects of retinoic acid on the proliferation of retinal cells", CHINESE JOURNAL OF OPHTHALMOLOGY - ZHONGHUA YAN KE ZA ZHI], vol. 38, no. 2, February 2002 (2002-02-01), pages 112 - 114, XP009518445, ISSN: 0412-4081
AKIMOTO, MASAYUKI: "Regenerative Medicine : Toward Curative Therapy for Retinal Degenerative Diseases", JOURNAL OF THE EYE, vol. 23, no. 9, 2006, pages 1153 - 1160, XP009518523, ISSN: 0910-1810
KELLEY MW ET AL.: "Retinoic acid promotes differentiation of photoreceptors in vitro", DEVELOPMENT, vol. 120, no. 8, 1994, pages 2091 - 2102, XP055562766, ISSN: 0950-1991
"Pharmacological approaches to retinitis pigmentosa: A laboratory perspective", PROG RETIN EYE RES., vol. 48, 2015, pages 62 - 81
"Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy", TRENDS IN MOLECULAR MEDICINE, vol. 11, 2005, pages 177 - 185
FARRAR GJKENNA PFHUMPHRIES P.: "On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention", EMBO J., vol. 21, no. 5, 2002, pages 857 - 864, XP002254684, DOI: 10.1093/emboj/21.5.857
HE YZHANG YLIU X ET AL.: "Recent advances of stem cell therapy for retinitis pigmentosa", INT. J. MOL. SCI., vol. 15, no. 8, 2014, pages 14456 - 14474
YU HVU THCHO K.: "Mobilizing endogenous stem cells for retinal repair", TRANSL. RES., vol. 163, no. 4, 2014, pages 387 - 398
KAMI JTAKAHASHI H ET AL.: "Retinoic acid receptor agonist Am90 inhibits experimental choroidal neovasucularization", INVEST. OPHTHALMOL. VIS. SCI., vol. 45, 2004, pages 1856
NAKAO TTSUJIKAWA MNOTOMI SIKEDA YNISHIDA K.: "The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa", PLOS ONE, vol. 7, no. 4, 2012, pages e32472
ORG. LETT., vol. 15, 2013, pages 3678 - 3681
EXP EYE RES., vol. 150, September 2016 (2016-09-01), pages 149 - 165
AM J OPHTHALMOL., vol. 168, August 2016 (2016-08-01), pages 260 - 268
BIOCHIM BIOPHYS ACTA-MOL CELL BIOL LIPID., vol. 1791, no. 7, July 2009 (2009-07-01), pages 573 - 583
PROG RETIN EYE RES., vol. 58, May 2017 (2017-05-01), pages 70 - 88
DEV OPHTHALMOL., vol. 53, 2014, pages 44 - 52
JPN J OPHTHALMOL., vol. 59, no. 2, March 2015 (2015-03-01), pages 71 - 80
J OPTOM., vol. 6, no. 2, April 2013 (2013-04-01), pages 114 - 122
NATURE, vol. 444, no. 7116, 9 November 2006 (2006-11-09), pages 203 - 207
SOROLDONI DHOGAN BMOATES AC.: "Simple and efficient transgenesis with meganuclease constructs in zebrafish.", METHODS MOL. BIOL., vol. 546, 2009, pages 117 - 130
HAMAOKA T1TAKECHI MCHINEN A ET AL.: "Visualization of rod photoreceptor development using GFP-transgenic zebrafish", GENESIS, vol. 34, no. 3, 2002, pages 215 - 220
See also references of EP 3650045A4
AKIMOTO, MASAYUKI: "Regenerative Medicine : Toward Curative Therapy for Retinal Degenerative Diseases", JOURNAL OF THE EYE, vol. 23, no. 9, 2006, pages 1153 - 1160, XP009518523, ISSN: 0910-1810
KELLEY MW ET AL.: "Retinoic acid promotes differentiation of photoreceptors in vitro", DEVELOPMENT, vol. 120, no. 8, 1994, pages 2091 - 2102, XP055562766, ISSN: 0950-1991
"Pharmacological approaches to retinitis pigmentosa: A laboratory perspective", PROG RETIN EYE RES., vol. 48, 2015, pages 62 - 81
"Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy", TRENDS IN MOLECULAR MEDICINE, vol. 11, 2005, pages 177 - 185
FARRAR GJKENNA PFHUMPHRIES P.: "On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention", EMBO J., vol. 21, no. 5, 2002, pages 857 - 864, XP002254684, DOI: 10.1093/emboj/21.5.857
HE YZHANG YLIU X ET AL.: "Recent advances of stem cell therapy for retinitis pigmentosa", INT. J. MOL. SCI., vol. 15, no. 8, 2014, pages 14456 - 14474
YU HVU THCHO K.: "Mobilizing endogenous stem cells for retinal repair", TRANSL. RES., vol. 163, no. 4, 2014, pages 387 - 398
KAMI JTAKAHASHI H ET AL.: "Retinoic acid receptor agonist Am90 inhibits experimental choroidal neovasucularization", INVEST. OPHTHALMOL. VIS. SCI., vol. 45, 2004, pages 1856
NAKAO TTSUJIKAWA MNOTOMI SIKEDA YNISHIDA K.: "The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa", PLOS ONE, vol. 7, no. 4, 2012, pages e32472
ORG. LETT., vol. 15, 2013, pages 3678 - 3681
EXP EYE RES., vol. 150, September 2016 (2016-09-01), pages 149 - 165
AM J OPHTHALMOL., vol. 168, August 2016 (2016-08-01), pages 260 - 268
BIOCHIM BIOPHYS ACTA-MOL CELL BIOL LIPID., vol. 1791, no. 7, July 2009 (2009-07-01), pages 573 - 583
PROG RETIN EYE RES., vol. 58, May 2017 (2017-05-01), pages 70 - 88
DEV OPHTHALMOL., vol. 53, 2014, pages 44 - 52
JPN J OPHTHALMOL., vol. 59, no. 2, March 2015 (2015-03-01), pages 71 - 80
J OPTOM., vol. 6, no. 2, April 2013 (2013-04-01), pages 114 - 122
NATURE, vol. 444, no. 7116, 9 November 2006 (2006-11-09), pages 203 - 207
SOROLDONI DHOGAN BMOATES AC.: "Simple and efficient transgenesis with meganuclease constructs in zebrafish.", METHODS MOL. BIOL., vol. 546, 2009, pages 117 - 130
HAMAOKA T1TAKECHI MCHINEN A ET AL.: "Visualization of rod photoreceptor development using GFP-transgenic zebrafish", GENESIS, vol. 34, no. 3, 2002, pages 215 - 220
See also references of EP 3650045A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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