Title:
DRUG SCREENING METHOD BASED ON DRUG DISCOVERY CONCEPT OF CANCER CELL PROLIFERATION INHIBITION INDUCED BY DISRUPTION OF CHROMOSOME REGULATION DUE TO PLK1 KINASE ACTIVATION
Document Type and Number:
WIPO Patent Application WO/2024/071401
Kind Code:
A1
Abstract:
The present inventors found that enhancement of Plk1 activity induces lethal chromosome dynamic abnormalities in cancer cells and inhibits the proliferation thereof. Thus, activation of Plk1 and exacerbation of chromosome instability can induce lethal chromosome dynamic abnormalities and inhibit cancer cell proliferation. Provided are a drug screening method and a pharmaceutical composition based on a novel drug discovery concept of inhibiting cancer cell proliferation by activating a kinase showing enhanced expression in cancer cells.
Inventors:
HIROTA TORU (JP)
TAKAHASHI MOTOKO (JP)
JO MINJI (JP)
KATO UTAKO (JP)
KAMAKURA NANA (JP)
KAWAKITA NORIKA (JP)
TAKAHASHI MOTOKO (JP)
JO MINJI (JP)
KATO UTAKO (JP)
KAMAKURA NANA (JP)
KAWAKITA NORIKA (JP)
Application Number:
PCT/JP2023/035706
Publication Date:
April 04, 2024
Filing Date:
September 29, 2023
Export Citation:
Assignee:
JAPANESE FOUND FOR CANCER RES (JP)
International Classes:
G01N33/50; A61K45/00; A61P35/00; A61P43/00; C07K14/47; C12N5/09; C12N9/12; C12Q1/48; G01N33/15; G01N33/573
Foreign References:
| JP2007525143A | 2007-09-06 | |||
| CN105030767A | 2015-11-11 |
Other References:
SUGUNADEVI SAKKIAH: "Dynamic and Multi-Pharmacophore Modeling for Designing Polo-Box Domain Inhibitors", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 9, no. 7, 1 July 2014 (2014-07-01), US , pages e101405, XP093154044, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0101405
ZHU KANG; SHAN ZELIN; ZHANG LU; WEN WENYU: "Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity", STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 7, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 1110 - 1119, XP029635755, ISSN: 0969-2126, DOI: 10.1016/j.str.2016.04.012
ZHU KANG; SHAN ZELIN; ZHANG LU; WEN WENYU: "Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity", STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 7, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 1110 - 1119, XP029635755, ISSN: 0969-2126, DOI: 10.1016/j.str.2016.04.012
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
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