Title:
DRUG FOR TREATING ARTERY-RELATED DISEASES, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/063366
Kind Code:
A1
Abstract:
Provided are a drug for treating artery-related diseases and the use thereof. Specifically, provided are the use of a class of compounds of formula I in the treatment of artery-related diseases. Experiments show that the compounds of formula I have a significant effect on aneurysm, intermural hematoma and/or arterial dissection.
Inventors:
JIANG BAOHONG (CN)
ZHANG XIANJING (CN)
DING YUCHAO (CN)
ZHAI ZIYI (CN)
ZHANG XIANJING (CN)
DING YUCHAO (CN)
ZHAI ZIYI (CN)
Application Number:
PCT/CN2020/118945
Publication Date:
April 08, 2021
Filing Date:
September 29, 2020
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/216; A61K31/05; A61K31/085; A61K31/12; A61K31/192; A61K31/352; A61K31/37; A61K31/621; A61P9/00
Foreign References:
| CN104055760A | 2014-09-24 | |||
| CN104749280A | 2015-07-01 | |||
| CN1477967A | 2004-02-25 | |||
| CN105079687A | 2015-11-25 | |||
| CN103298465A | 2013-09-11 | |||
| CN101411746A | 2009-04-22 | |||
| CN107320552A | 2017-11-07 | |||
| CN105017034A | 2015-11-04 | |||
| CN103893325A | 2014-07-02 | |||
| CN102309477A | 2012-01-11 |
Other References:
CAO CHUN SHUI ,ZHAN ZUAN ,DU HUAN ,LUO XIAO LONG ,LIU RI SHENG ,HUANG LIANG: "Caffeic Acid Phenethyl Ester Inhibits the Progression of Elastase Induced Aortic Aneurysm in Rats", INTERNATIONAL JOURNAL OF PHARMACOLOGY, vol. 15, no. 3, 15 March 2019 (2019-03-15), pages 385 - 393, XP009527043, DOI: 10.3923/ijp.2019.385.393
LI GUANGZHONG ,CHEN FENGYAN ,ZHONG QIN , WU NI: "The clinical application of warfarin in children with Kawasaki disease complicated by coronary artery aneurysm", ELECTRONIC JOURNAL OF GENERAL STOMATOLOGY, vol. 6, no. 23, 31 August 2019 (2019-08-31), pages 149 - 150, XP055797066, DOI: 10.16269/j.cnki.cn11-9337/r.2019.23.104
WU PENG, HAN NA, YU HAITAO, WANG LINLIN, LI XUE, DONG ZHIHUI, FU WEIGUO, YORINAKA HOICHI, CHO KENKA, WU WANYING, LIU XUAN, YANG MI: "Amelioration of Salvianolic Acid C on Aortic Structure in Apolipoprotein E-deficient Mice Treated with Angiotension II", LIFE SCIENCE, vol. 166, 1 December 2016 (2016-12-01), pages 75 - 81, XP055797073, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2016.09.012
TINGTING ZHANG; JINGHUA XU; DEFANG LI; JING CHEN; XU SHEN; FENG XU; FUKANG TENG; YANPING DENG; HONGMEI MA; LI ZHANG; GE ZHANG; ZHO: "Salvianolic Acid A, a Matrix Metalloproteinase-9 Inhibitor of Salvia Miltiorrhiza, Attenuates Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice", PHYTOMEDICINE, vol. 21, no. 10, 15 September 2014 (2014-09-15), pages 1137 - 1145, XP055797084, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2014.05.003
"TCM diagnostic efficacy criteria for heart disease and medication specifications", 28 February 2002, BEIJING PUBLISHING HOUSE, CN, ISBN: 7-200-04435-0, article SHEN SHAOGONG: "Aortic Aneurysm and Aortic Dissecting Aneurysm", pages: 118 - 122, XP009527583
KAMILA ZDUŃSKA , AGNIESZKA DANA , ANNA KOLODZIEJCZAK , HELENA ROTSZTEJN: "Antioxidant Properties of Ferulic Acid and Its Possible Application", SKIN PHARMACOLOGY AND PHYSIOLOGY, vol. 31, no. 6, 1 October 2018 (2018-10-01), pages 332 - 336, XP055797095, ISSN: 1660-5527, DOI: 10.1159/000491755
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T.W.GREENEP.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESERM.FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
See also references of EP 4043012A4
LI GUANGZHONG ,CHEN FENGYAN ,ZHONG QIN , WU NI: "The clinical application of warfarin in children with Kawasaki disease complicated by coronary artery aneurysm", ELECTRONIC JOURNAL OF GENERAL STOMATOLOGY, vol. 6, no. 23, 31 August 2019 (2019-08-31), pages 149 - 150, XP055797066, DOI: 10.16269/j.cnki.cn11-9337/r.2019.23.104
WU PENG, HAN NA, YU HAITAO, WANG LINLIN, LI XUE, DONG ZHIHUI, FU WEIGUO, YORINAKA HOICHI, CHO KENKA, WU WANYING, LIU XUAN, YANG MI: "Amelioration of Salvianolic Acid C on Aortic Structure in Apolipoprotein E-deficient Mice Treated with Angiotension II", LIFE SCIENCE, vol. 166, 1 December 2016 (2016-12-01), pages 75 - 81, XP055797073, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2016.09.012
TINGTING ZHANG; JINGHUA XU; DEFANG LI; JING CHEN; XU SHEN; FENG XU; FUKANG TENG; YANPING DENG; HONGMEI MA; LI ZHANG; GE ZHANG; ZHO: "Salvianolic Acid A, a Matrix Metalloproteinase-9 Inhibitor of Salvia Miltiorrhiza, Attenuates Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice", PHYTOMEDICINE, vol. 21, no. 10, 15 September 2014 (2014-09-15), pages 1137 - 1145, XP055797084, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2014.05.003
"TCM diagnostic efficacy criteria for heart disease and medication specifications", 28 February 2002, BEIJING PUBLISHING HOUSE, CN, ISBN: 7-200-04435-0, article SHEN SHAOGONG: "Aortic Aneurysm and Aortic Dissecting Aneurysm", pages: 118 - 122, XP009527583
KAMILA ZDUŃSKA , AGNIESZKA DANA , ANNA KOLODZIEJCZAK , HELENA ROTSZTEJN: "Antioxidant Properties of Ferulic Acid and Its Possible Application", SKIN PHARMACOLOGY AND PHYSIOLOGY, vol. 31, no. 6, 1 October 2018 (2018-10-01), pages 332 - 336, XP055797095, ISSN: 1660-5527, DOI: 10.1159/000491755
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T.W.GREENEP.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESERM.FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
See also references of EP 4043012A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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