Title:
DRUG FOR TREATING MANIC MENTAL DISORDER AND SCHIZOPHRENIA
Document Type and Number:
WIPO Patent Application WO/2020/233706
Kind Code:
A1
Abstract:
A drug for treating a manic mental disorder and schizophrenia, specifically, a guanine nucleoside as represented by formula I and a use of a derivative thereof in treating mental disorders such as a manic mental disorder and schizophrenia.
Inventors:
LI HONGLIN (CN)
WANG RUI (CN)
ZHANG SHOUDE (CN)
ZHAO ZHENJIANG (CN)
MAO YU (CN)
WANG RUI (CN)
ZHANG SHOUDE (CN)
ZHAO ZHENJIANG (CN)
MAO YU (CN)
Application Number:
PCT/CN2020/091796
Publication Date:
November 26, 2020
Filing Date:
May 22, 2020
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
International Classes:
A61K31/708; A61P25/18; A61P25/20
Domestic Patent References:
| WO1994000132A1 | 1994-01-06 | |||
| WO2014039809A2 | 2014-03-13 | |||
| WO2015034928A1 | 2015-03-12 |
Foreign References:
| CN1154065A | 1997-07-09 | |||
| CN1286258A | 2001-03-07 |
Other References:
SCHMIDT, A.P. ET AL.: "Guanosine and its modulatory effects on the glutamatergic system.", EUROPEAN NEUROPSYCHOPHARMACOLOGY., vol. 18, no. 8, 31 August 2008 (2008-08-31), pages 620 - 622, XP022778057, ISSN: 0924-977X
THE NUCLEIC ACID SYNTHESIS GROUP, SECOND LABORATORY, SHANGHAI INSTITUTE OF BIOCHEMISTRY, ACADEMIA SINICA): "STUDIES ON POLYNUCLEOTIDE SYNTHESIS, Ⅺ. SYNTHESIS OF THE TETRANUCLEOSIDE TRIPHOSPHATE CpGpCpm_2~2G OF THE 5'-HALF MOLECULE OF YEAST ALANINE TRANSFER RNA)", ACTA BIOCHIMICA ET BIOPHYSICA SINICA, vol. 12, no. 1,, 31 March 1980 (1980-03-31), ISSN: 1672-9145
KRSTULJA, A. ET AL.: "Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.", JOURNAL OF CHROMATOGRAPHY A., vol. 1365, 24 October 2014 (2014-10-24), ISSN: 0021-9673, DOI: 20200820162813X
PUTHENVEETIL, S. ET AL.: "Site-specific modification of Epstein-Barr virus-encoded RNA 1 with N2-benzylguanosine limits the binding sites occupied by PKR.", CHEMBIOCHEM., vol. 5, no. 3, 5 March 2004 (2004-03-05), ISSN: 1439-4227, DOI: 20200820163145X
BRIDSON, P.K. ET AL.: "A novel method for the methylation of heterocyclic amino groups. Conversion of guanosine into its 2-N-methyl- and 2-N, 2-N-dimethyl derivatives.", BIOORGANIC CHEMISTRY., vol. 8, no. 3, 30 September 1979 (1979-09-30), XP024022811, ISSN: 0045-2068, DOI: 20200820163630X
BRIDSON, P.K. ET AL.: "Conversion of guanosine into its N2-methyl derivative.", CHEMISCHER INFORMATIONSDIENST., vol. 8, no. 46, 15 November 1977 (1977-11-15), ISSN: 1522-2667, DOI: 20200820163932X
KOENIG, W.A. ET AL.: "Mass spectrometry of trifluoroacetyl derivatives of nucleosides and hydrolysates of deoxyribonucleic acid.", BIOCHEMISTRY., vol. 10, no. 21, 12 October 1971 (1971-10-12), ISSN: 0006-2960, DOI: 20200820164147X
THE NUCLEIC ACID SYNTHESIS GROUP, SECOND LABORATORY, SHANGHAI INSTITUTE OF BIOCHEMISTRY, ACADEMIA SINICA): "STUDIES ON POLYNUCLEOTIDE SYNTHESIS, Ⅺ. SYNTHESIS OF THE TETRANUCLEOSIDE TRIPHOSPHATE CpGpCpm_2~2G OF THE 5'-HALF MOLECULE OF YEAST ALANINE TRANSFER RNA)", ACTA BIOCHIMICA ET BIOPHYSICA SINICA, vol. 12, no. 1,, 31 March 1980 (1980-03-31), ISSN: 1672-9145
KRSTULJA, A. ET AL.: "Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.", JOURNAL OF CHROMATOGRAPHY A., vol. 1365, 24 October 2014 (2014-10-24), ISSN: 0021-9673, DOI: 20200820162813X
PUTHENVEETIL, S. ET AL.: "Site-specific modification of Epstein-Barr virus-encoded RNA 1 with N2-benzylguanosine limits the binding sites occupied by PKR.", CHEMBIOCHEM., vol. 5, no. 3, 5 March 2004 (2004-03-05), ISSN: 1439-4227, DOI: 20200820163145X
BRIDSON, P.K. ET AL.: "A novel method for the methylation of heterocyclic amino groups. Conversion of guanosine into its 2-N-methyl- and 2-N, 2-N-dimethyl derivatives.", BIOORGANIC CHEMISTRY., vol. 8, no. 3, 30 September 1979 (1979-09-30), XP024022811, ISSN: 0045-2068, DOI: 20200820163630X
BRIDSON, P.K. ET AL.: "Conversion of guanosine into its N2-methyl derivative.", CHEMISCHER INFORMATIONSDIENST., vol. 8, no. 46, 15 November 1977 (1977-11-15), ISSN: 1522-2667, DOI: 20200820163932X
KOENIG, W.A. ET AL.: "Mass spectrometry of trifluoroacetyl derivatives of nucleosides and hydrolysates of deoxyribonucleic acid.", BIOCHEMISTRY., vol. 10, no. 21, 12 October 1971 (1971-10-12), ISSN: 0006-2960, DOI: 20200820164147X
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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