Title:
DRUG FOR TREATING UROLITHIASIS-RELATED DISEASE, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/151978
Kind Code:
A1
Abstract:
Provided in the present invention is a pharmaceutically active ingredient extract extracted from Polygala japonica Houtt., which extract comprises a flavonol compound of the following formula (I) structure as a first active ingredient, and optionally comprises a xanthone compound selected from the following formula (II) as a second active ingredient and a glycolipid compound selected from the following formula (III-1) as a third active ingredient. An animal experiment confirms that the drug of the present invention has significantly better effects than sodium potassium hydrogen citrate in typical test indicators such as calcium oxalate crystal aggregation, renal interstitial inflammatory cell infiltration and renal tubule dilation lesions, showing that the drug has high potential and market prospects in the treatment of urolithiasis and urinary tract infections or kidney damage caused by urolithiasis, and as an adjuvant drug after surgical treatment of urolithiasis.
Inventors:
ZHANG HONG (CN)
WANG KUIWU (CN)
GUI QIAN (CN)
WANG KUIWU (CN)
GUI QIAN (CN)
Application Number:
PCT/CN2021/142460
Publication Date:
July 21, 2022
Filing Date:
December 29, 2021
Export Citation:
Assignee:
ZHANG HONG (CN)
International Classes:
C07H17/07; A61K31/7048; A61P13/02; A61P13/12; C07H1/08
Foreign References:
| CN114031656A | 2022-02-11 |
Other References:
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HARAGUCHI, MITSUE ET AL.: "Triterpenoid saponins and flavonol glycosides from Phytolacca thyrsiflora", PHYTOCHEMISTRY, vol. 27, no. 7, 31 December 1988 (1988-12-31), XP026616013, DOI: 10.1016/0031-9422(88)80145-6
T.-Z. LI, W.-D. ZHANG, G.-J. YANG, W.-Y. LIU, R.-H. LIU, C. ZHANG & H.-S. CHEN: "New flavonol glycosides and new xanthone from Polygala Japonica", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, vol. 8, no. 5, 31 August 2006 (2006-08-31), CH , pages 401 - 409, XP009538381, ISSN: 1028-6020, DOI: 10.1080/10286020500172558
ZHANG JINGJING, ET AL. : "Advances on Chemical Constituents and Pharmacological Activities of Polygala japonica Houtt", MODERN CHINESE MEDICINE, ZHONG GUO XIAN DAI ZHONG YAO BIAN JI BU, CN, vol. 17, no. 11, 30 November 2015 (2015-11-30), CN , pages 1216 - 1222, XP055951238, ISSN: 1673-4890, DOI: 10.13313/j.issn.1673-4890.2015.11.025
LI TINZHAO: "Bio-Assay Guided Isolation of the Anti-Depressive Constituents of Polygala Japonica Houtt. & Studies on the Active Constituents of Patrinia Scabra", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (DOCTOR), MEDICINE & PUBLIC HEALTH, 15 October 2005 (2005-10-15), XP055951209
WU JIANFENG: "Studies on the Chemical Constituents and Biological Activities from Two Medicinal Plants of Polygala", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (DOCTOR), MEDICINE & PUBLIC HEALTH, 15 November 2007 (2007-11-15), XP055951237, ISBN: 978-4-582-94614-7
JIANG, Y.; ZHANG, W.; TU, P.*; XU, X.: "Xanthone glycosides from Polygala tenuifolia and their conformational analyses", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 27, no. 6, 1 December 2005 (2005-12-01), Scientific Publishers, New Delhi - India , XP018006943, ISSN: 0250-4367
DONG, MEIYUE ET AL.: "Chemical constituents from the seeds of Raphanus sativus L. and their chemotaxonomic significance", BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol. 93, 8 September 2020 (2020-09-08), XP086345656, DOI: 10.1016/j.bse.2020.104138
ZHAO X"; XU B; WU P; ZHAO P; GUO C; CUI Y; ZHANG Y; ZHANG X;" LI H: "UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma", PHARMACEUTICAL BIOLOGY, SWETS AND ZEITLINGER, LISSE,, NL, 1 June 2020 (2020-06-01), NL , pages 969 - 978, XP018538039, ISSN: 1388-0209
GODA YUKIHIRO, ET AL.: "Constituents in watercress: inhibitors of histamine release from RBL-2H3 cells induced by antigen stimulation", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 22, no. 12, 31 December 1999 (1999-12-31), pages 1319 - 1326, XP055951204, DOI: 10.1248/bpb.22.1319
MAJUMDER RANABIR, MANDAL MAHITOSH: "Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: an in silico docking and molecular dynamics simulation approach", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 40, no. 2, 22 January 2022 (2022-01-22), US , pages 696 - 711, XP055951202, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1817787
LI WENKUI, ET AL.: "A Study on Chemical Constituents of Polygala Japonica", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, GAI KAN BIANJIBU, CHENGDU, CN, vol. 8, no. 3, 30 September 1996 (1996-09-30), CN , pages 1 - 4, XP055951200, ISSN: 1001-6880, DOI: 10.16333/j.1001-6880.1996.03.001
HARAGUCHI, MITSUE ET AL.: "Triterpenoid saponins and flavonol glycosides from Phytolacca thyrsiflora", PHYTOCHEMISTRY, vol. 27, no. 7, 31 December 1988 (1988-12-31), XP026616013, DOI: 10.1016/0031-9422(88)80145-6
T.-Z. LI, W.-D. ZHANG, G.-J. YANG, W.-Y. LIU, R.-H. LIU, C. ZHANG & H.-S. CHEN: "New flavonol glycosides and new xanthone from Polygala Japonica", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, vol. 8, no. 5, 31 August 2006 (2006-08-31), CH , pages 401 - 409, XP009538381, ISSN: 1028-6020, DOI: 10.1080/10286020500172558
ZHANG JINGJING, ET AL. : "Advances on Chemical Constituents and Pharmacological Activities of Polygala japonica Houtt", MODERN CHINESE MEDICINE, ZHONG GUO XIAN DAI ZHONG YAO BIAN JI BU, CN, vol. 17, no. 11, 30 November 2015 (2015-11-30), CN , pages 1216 - 1222, XP055951238, ISSN: 1673-4890, DOI: 10.13313/j.issn.1673-4890.2015.11.025
LI TINZHAO: "Bio-Assay Guided Isolation of the Anti-Depressive Constituents of Polygala Japonica Houtt. & Studies on the Active Constituents of Patrinia Scabra", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (DOCTOR), MEDICINE & PUBLIC HEALTH, 15 October 2005 (2005-10-15), XP055951209
WU JIANFENG: "Studies on the Chemical Constituents and Biological Activities from Two Medicinal Plants of Polygala", CHINESE DOCTORAL DISSERTATIONS & MASTER'S THESES FULL-TEXT DATABASE (DOCTOR), MEDICINE & PUBLIC HEALTH, 15 November 2007 (2007-11-15), XP055951237, ISBN: 978-4-582-94614-7
JIANG, Y.; ZHANG, W.; TU, P.*; XU, X.: "Xanthone glycosides from Polygala tenuifolia and their conformational analyses", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 27, no. 6, 1 December 2005 (2005-12-01), Scientific Publishers, New Delhi - India , XP018006943, ISSN: 0250-4367
DONG, MEIYUE ET AL.: "Chemical constituents from the seeds of Raphanus sativus L. and their chemotaxonomic significance", BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol. 93, 8 September 2020 (2020-09-08), XP086345656, DOI: 10.1016/j.bse.2020.104138
ZHAO X"; XU B; WU P; ZHAO P; GUO C; CUI Y; ZHANG Y; ZHANG X;" LI H: "UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma", PHARMACEUTICAL BIOLOGY, SWETS AND ZEITLINGER, LISSE,, NL, 1 June 2020 (2020-06-01), NL , pages 969 - 978, XP018538039, ISSN: 1388-0209
GODA YUKIHIRO, ET AL.: "Constituents in watercress: inhibitors of histamine release from RBL-2H3 cells induced by antigen stimulation", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 22, no. 12, 31 December 1999 (1999-12-31), pages 1319 - 1326, XP055951204, DOI: 10.1248/bpb.22.1319
MAJUMDER RANABIR, MANDAL MAHITOSH: "Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: an in silico docking and molecular dynamics simulation approach", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 40, no. 2, 22 January 2022 (2022-01-22), US , pages 696 - 711, XP055951202, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1817787
LI WENKUI, ET AL.: "A Study on Chemical Constituents of Polygala Japonica", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, GAI KAN BIANJIBU, CHENGDU, CN, vol. 8, no. 3, 30 September 1996 (1996-09-30), CN , pages 1 - 4, XP055951200, ISSN: 1001-6880, DOI: 10.16333/j.1001-6880.1996.03.001
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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