Title:
DRUGS COMPRISING COMBINATION OF ELASTASE INHIBITOR WITH BLOOD COAGULATION SYSTEM AND/OR FIBRINOLYSIS SYSTEM ENZYME INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2004/041309
Kind Code:
A1
Abstract:
A drug comprising a combination of an elastase inhibitor comprising, for example, a compound represented by the general formula (IA) or a nontoxic salt thereof with a blood coagulation system and/or fibrinolysis system enzyme inhibitor comprising, for example, compounds represented by the general formulae (IIB), (IIC), (IID) and (IIE), an aprotinin derivative, an antithrombin III derivative, a heparin derivative, a danaparoid sodium derivative, a hirudin derivative, a thrombomodulin derivative, a sulfated sugar or a nontoxic salt thereof. The above drug is useful in preventing and/or treating acute lung injury, disseminated intravascular coagulation and multiorgan failure in liver, kidney, etc. and improving the prognosis of a patient.
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Inventors:
KAWABATA KAZUHITO (JP)
MATSUMOTO SHIGERU (JP)
MATSUMOTO SHIGERU (JP)
Application Number:
PCT/JP2003/014198
Publication Date:
May 21, 2004
Filing Date:
November 07, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
KAWABATA KAZUHITO (JP)
MATSUMOTO SHIGERU (JP)
KAWABATA KAZUHITO (JP)
MATSUMOTO SHIGERU (JP)
International Classes:
A61K31/222; A61K31/275; A61K31/40; A61K31/445; A61K31/4535; A61K31/454; A61K31/4709; A61K31/727; A61K38/17; A61K38/55; A61K38/57; A61K38/58; A61K45/06; A61P7/02; A61P11/00; A61P43/00; (IPC1-7): A61K45/06; A61K31/222; A61K31/275; A61K31/40; A61K31/445; A61K31/4535; A61K31/454; A61K31/4709; A61K31/727; A61K38/17; A61K38/55; A61K38/58; A61P7/02; A61P11/00; A61P43/00
Domestic Patent References:
| WO2001049323A1 | 2001-07-12 | |||
| WO1980001383A1 | 1980-07-10 | |||
| WO1998053829A1 | 1998-12-03 |
Foreign References:
| EP0347168A1 | 1989-12-20 | |||
| GB1324714A | 1973-07-25 | |||
| EP0048433A2 | 1982-03-31 | |||
| EP0540051A1 | 1993-05-05 | |||
| EP0008746A1 | 1980-03-19 | |||
| EP0040144A1 | 1981-11-18 | |||
| EP0324712A2 | 1989-07-19 | |||
| EP0376251A2 | 1990-07-04 | |||
| EP0312598A1 | 1989-04-26 | |||
| EP0511393A1 | 1992-11-04 | |||
| EP0066908A1 | 1982-12-15 | |||
| US4818816A | 1989-04-04 |
Other References:
REDENS T. B. ET AL: "Synergistic protection from lung damage by combining antithrombin-III and alpha1-proteinase inhibitor in the E. coli endotoxemic sheep pulmonary dysfunction model", CIRCULATORY SHOCK, vol. 26, no. 1, 1988, pages 15 - 26, XP000990458
YAMAGUCHI Y. ET AL: "Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver", GASTROENTEROLOGY, vol. 112, no. 2, 1997, pages 551 - 560, XP002977466
YAMAGUCHI Y. ET AL: "Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein-1 expression after ischemia/reperfusion in rat liver", TRANSPLANTATION, vol. 68, no. 10, 1999, pages 1459 - 1468, XP000994937
FAHY J. V. ET AL: "Mucus hypersecretion in bronchiectasis: The role of neutrophil proteases", AMERICAN REVIEW OF RESPIRATORY DISEASE, vol. 146, no. 6, 1992, pages 1430 - 1433, XP000929354
FRIC P. ET AL: "Effective peritoneal therapy of acute pancreatitis in the rat with glutaryl-trialanin-ethylamide: A novel inhibitor of pancreatic elastase", GUT, vol. 33, no. 5, 1992, pages 701 - 706, XP002977467
CEJKOVA J. ET AL: "Histochemical changes in the rabbit cornea and plasmin activity in the tear fluid during contact lens wear. Favorable influence of protease inhibitors (aprotinin, PC5, elastatinal)", HISTOCHEMISTRY, vol. 97, no. 1, 1992, pages 69 - 76, XP002934286
UCHIDA M. ET AL: "Recombinant Human Soluble Thrombomodulin reduces Endotoxin-Induced Pulmonary Vascular Injury Via Protein C Activation in Rats", THROMBOSIS AND HAEMOSTASIS, vol. 74, no. 5, 1995, pages 1265 - 1270, XP002977468
HAGIO TETSUYA ET AL: "Hotai Izonsei Hamster Hai Shogai Model ni Okeru Tokuiteki Kochukyu Elastase Sogaizai, ONO-5046.Na no Yukosei", KISO TO RINSHO (CLINICAL REPORT), vol. 31, no. 2, 1997, pages 3357 - 3365, XP002980148
NAKAO SHINTARO ET AL: "Kochukyu Elastase Sogazai, ONO-5046.Na no in vivo, ex vivo oyobi in vivo ni Okeru Yakurigakuteki Tokucho", KISO TO RINSHO (CLINICAL REPORT), vol. 31, no. 2, 1997, pages 3347 - 3356, XP002980149
KAWABATA K. ET AL: "Kochukyu Elastase to Kyusei Hai Shogai", THE TISSUE CULTURE ENGINEERING, vol. 27, no. 9, 2001, pages 29 - 33 (355-359), XP002980150
KAWABATA K. ET AL: "Tokushu Yakuzai Yuki Hai Shogai-Saikin no Mondai Kiso Igaku tono Dialogue ONO-5046.Na no Sayo Kiko", THE LUNG PERSPECTIVE, vol. 7, no. 2, 1999, pages 66 - 72 (178-184), XP002980151
YAMAGUCHI Y. ET AL: "Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver", GASTROENTEROLOGY, vol. 112, no. 2, 1997, pages 551 - 560, XP002977466
YAMAGUCHI Y. ET AL: "Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein-1 expression after ischemia/reperfusion in rat liver", TRANSPLANTATION, vol. 68, no. 10, 1999, pages 1459 - 1468, XP000994937
FAHY J. V. ET AL: "Mucus hypersecretion in bronchiectasis: The role of neutrophil proteases", AMERICAN REVIEW OF RESPIRATORY DISEASE, vol. 146, no. 6, 1992, pages 1430 - 1433, XP000929354
FRIC P. ET AL: "Effective peritoneal therapy of acute pancreatitis in the rat with glutaryl-trialanin-ethylamide: A novel inhibitor of pancreatic elastase", GUT, vol. 33, no. 5, 1992, pages 701 - 706, XP002977467
CEJKOVA J. ET AL: "Histochemical changes in the rabbit cornea and plasmin activity in the tear fluid during contact lens wear. Favorable influence of protease inhibitors (aprotinin, PC5, elastatinal)", HISTOCHEMISTRY, vol. 97, no. 1, 1992, pages 69 - 76, XP002934286
UCHIDA M. ET AL: "Recombinant Human Soluble Thrombomodulin reduces Endotoxin-Induced Pulmonary Vascular Injury Via Protein C Activation in Rats", THROMBOSIS AND HAEMOSTASIS, vol. 74, no. 5, 1995, pages 1265 - 1270, XP002977468
HAGIO TETSUYA ET AL: "Hotai Izonsei Hamster Hai Shogai Model ni Okeru Tokuiteki Kochukyu Elastase Sogaizai, ONO-5046.Na no Yukosei", KISO TO RINSHO (CLINICAL REPORT), vol. 31, no. 2, 1997, pages 3357 - 3365, XP002980148
NAKAO SHINTARO ET AL: "Kochukyu Elastase Sogazai, ONO-5046.Na no in vivo, ex vivo oyobi in vivo ni Okeru Yakurigakuteki Tokucho", KISO TO RINSHO (CLINICAL REPORT), vol. 31, no. 2, 1997, pages 3347 - 3356, XP002980149
KAWABATA K. ET AL: "Kochukyu Elastase to Kyusei Hai Shogai", THE TISSUE CULTURE ENGINEERING, vol. 27, no. 9, 2001, pages 29 - 33 (355-359), XP002980150
KAWABATA K. ET AL: "Tokushu Yakuzai Yuki Hai Shogai-Saikin no Mondai Kiso Igaku tono Dialogue ONO-5046.Na no Sayo Kiko", THE LUNG PERSPECTIVE, vol. 7, no. 2, 1999, pages 66 - 72 (178-184), XP002980151
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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