Title:
DRUGS CONTAINING AS THE ACTIVE INGREDIENT MIDKINE OR INHIBITORS THEREOF
Document Type and Number:
WIPO Patent Application WO/1999/003493
Kind Code:
A1
Abstract:
Drugs for treating neutrophilic functional disorders or inflammatory diseases, containing as the active ingredient midkine (MK), which is a retinoic acid-inducible heparin-binding growth factor found to enhance the neutrophile migration and to exist at a high concentration in an inflammatory state, or inhibitors thereof.
Inventors:
Takada, Tohru (Dept. of Biochemistry, School of Medicine Nagoya University 65 Tsurumai-cho, Showa-ku Nagoya-shi Aichi, 466-0065, JP)
Toriyama, Kazuhiro (Dept. of Plastic and Reconstructive Surgery School of Medicine, Nagoya University 65 Tsurumai-cho Showa-ku, Nagoya-shi Aichi, 466-0065, JP)
Muramatsu, Hisako (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Muramatsu, Takashi (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Toriyama, Kazuhiro (Dept. of Plastic and Reconstructive Surgery School of Medicine, Nagoya University 65 Tsurumai-cho Showa-ku, Nagoya-shi Aichi, 466-0065, JP)
Muramatsu, Hisako (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Muramatsu, Takashi (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Application Number:
PCT/JP1998/003161
Publication Date:
January 28, 1999
Filing Date:
July 14, 1998
Export Citation:
Assignee:
MEIJI MILK PRODUCTS CO., LTD. (3-6 Kyobashi 2-chome Chuo-ku Tokyo, 104-0031, JP)
Takada, Tohru (Dept. of Biochemistry, School of Medicine Nagoya University 65 Tsurumai-cho, Showa-ku Nagoya-shi Aichi, 466-0065, JP)
Toriyama, Kazuhiro (Dept. of Plastic and Reconstructive Surgery School of Medicine, Nagoya University 65 Tsurumai-cho Showa-ku, Nagoya-shi Aichi, 466-0065, JP)
Muramatsu, Hisako (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Muramatsu, Takashi (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Takada, Tohru (Dept. of Biochemistry, School of Medicine Nagoya University 65 Tsurumai-cho, Showa-ku Nagoya-shi Aichi, 466-0065, JP)
Toriyama, Kazuhiro (Dept. of Plastic and Reconstructive Surgery School of Medicine, Nagoya University 65 Tsurumai-cho Showa-ku, Nagoya-shi Aichi, 466-0065, JP)
Muramatsu, Hisako (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
Muramatsu, Takashi (2845-161, Aza Kuroishi Oaza Hirabari Tenpaku-cho, Tenpaku-ku Nagoya-shi Aichi, 468-0021, JP)
International Classes:
A61K38/18; A61K38/19; (IPC1-7): A61K38/17; A61K39/395; A61K31/725; A61K45/00; A61K38/20
Attorney, Agent or Firm:
Shimizu, Hatsushi (Kantetsu Tsukuba Building 6F 1-1-1, Oroshi-machi Tsuchiura-shi Ibaraki, 300-0847, JP)
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