Title:
DRY POWDER INHALER
Document Type and Number:
WIPO Patent Application WO/2015/054124
Kind Code:
A3
Abstract:
This invention provides a dry powder inhaler comprising: a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of salmeterol per actuation is less than 50 μg; and wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose. A method of treating a patient includes administering to a patient a dry powder medicament having fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of salmeterol per actuation is less than 50 μg; and wherein the dose provides a baseline-adjusted FEV1in a patient of more than 150 mL within 30 minutes of receiving the dose.
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Inventors:
DALVI MUKUL (US)
TEE SEAH KEE (US)
TEE SEAH KEE (US)
Application Number:
PCT/US2014/059285
Publication Date:
September 03, 2015
Filing Date:
October 06, 2014
Export Citation:
Assignee:
TEVA BRANDED PHARMACEUTICAL PROD R & D INC (US)
International Classes:
A61K9/12; A61K31/137; A61K31/56; A61M15/00
Domestic Patent References:
| WO2011145109A1 | 2011-11-24 | |||
| WO2001097889A2 | 2001-12-27 | |||
| WO2002000281A2 | 2002-01-03 | |||
| WO2011054527A1 | 2011-05-12 |
Other References:
NELSON H S ET AL: "Efficacy and safety of fluticasone propionate 44 1/4g/salmeterol 21 1/4g administeredin a hydrofluoroalkane metered-dose inhaleras an initial asthma maintenance treatment", ANNALS OF ALLERGY, ASTHMA & IMMUNOLOGY, ARLINGTON HEIGHTS, IL, US, vol. 91, no. 3, 1 September 2003 (2003-09-01), pages 263 - 269, XP026974851, ISSN: 1081-1206, [retrieved on 20030901]
COPLEY SCIENTIFIC: "Quality solutions for inhaler testing", 2012, pages 1 - 108, XP002740714, Retrieved from the Internet [retrieved on 20151006]
COPLEY SCIENTIFIC: "Quality solutions for inhaler testing", 2012, pages 1 - 108, XP002740714, Retrieved from the Internet
Attorney, Agent or Firm:
HARPER, Stephen, D. (P.O. Box 980Valley Forge, PA, US)
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