Title:
DSG2-DERIVED PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2017/211273
Kind Code:
A1
Abstract:
Provided herein are Dsg2-derived peptides for inhibiting EMT and/or vasculogenic mimicry and treating and/or preventing angiogenesis-related diseases. Also provided are pharmaceutical compositions comprising the peptides of the invention and methods of using the peptides of the invention in inhibiting EMT and/or vasculogenic mimicry, and treating and/or preventing angiogenesis-related diseases.
Inventors:
CHEN MIN-CHE (CN)
CHEN CHUN-WEI (CN)
CHEN CHUN-WEI (CN)
Application Number:
PCT/CN2017/087336
Publication Date:
December 14, 2017
Filing Date:
June 06, 2017
Export Citation:
Assignee:
ASCLEPIUMM TAIWAN CO LTD (CN)
International Classes:
A61K38/08; C07K16/28; A61P35/00
Domestic Patent References:
| WO2011036440A1 | 2011-03-31 | |||
| WO2015165392A1 | 2015-11-05 | |||
| WO1999057149A2 | 1999-11-11 |
Foreign References:
| US20040229811A1 | 2004-11-18 | |||
| US20120276082A1 | 2012-11-01 |
Other References:
OTA, T. ET AL.: "No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases", JOURNAL OF DERMATOLOGICAL SCIENCE ., vol. 32, no. 2, 31 August 2003 (2003-08-31), pages 137 - 141, XP055234756
GIUSTI, B. ET AL.: "Desmoglein-2-Integrin Beta-8 Interaction Regulates Actin Assembly in Endothelial Cells: Deregulation in Systemic Sclerosis", PLOS ONE ., vol. 8, no. 7, 11 July 2013 (2013-07-11), XP055234757
BRENNAN, D. ET AL.: "Increased expression of Dsg2 in malignant skin carcinomas", CELL ADHESION & MIGRATION., vol. 3, no. 2, 30 June 2009 (2009-06-30), pages 148 - 154, XP008163216
NAVA, P. ET AL.: "Desmoglein-2: A Novel Regulator of Apoptosis in the Intestinal Epithelium", MOLECULAR BIOLOGY OF THE CELL, vol. 18, 5 September 2007 (2007-09-05), pages 4565 - 4578, XP055234754
GIUSTI, B. ET AL.: "Desmoglein-2-Integrin Beta-8 Interaction Regulates Actin Assembly in Endothelial Cells: Deregulation in Systemic Sclerosis", PLOS ONE ., vol. 8, no. 7, 11 July 2013 (2013-07-11), XP055234757
BRENNAN, D. ET AL.: "Increased expression of Dsg2 in malignant skin carcinomas", CELL ADHESION & MIGRATION., vol. 3, no. 2, 30 June 2009 (2009-06-30), pages 148 - 154, XP008163216
NAVA, P. ET AL.: "Desmoglein-2: A Novel Regulator of Apoptosis in the Intestinal Epithelium", MOLECULAR BIOLOGY OF THE CELL, vol. 18, 5 September 2007 (2007-09-05), pages 4565 - 4578, XP055234754
Attorney, Agent or Firm:
LEE AND LI - LEAVEN IPR AGENCY LTD. (CN)
Download PDF: