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Title:
DUAL ALANYL AMINOPEPTIDASE AND DIPEPTIDYL PEPTIDASE IV INHIBITORS FOR FUNCTIONALLY INFLUENCING DIFFERENT CELLS AND FOR TREATING IMMUNOLOGICAL, INFLAMMATORY, NEURONAL AND OTHER DISEASES
Document Type and Number:
WIPO Patent Application WO2005034940
Kind Code:
A3
Abstract:
The invention relates to substances, which specifically inhibit both Ala-p-nitroanilide-cleaving peptidases as well as Gly-Pro-p-nitroanilide-cleaving peptidases, for use in the field of medicine. The invention also relates to the use of at least one substance of this type or of at least one pharmaceutical or cosmetic composition, which contains at least one of the aforementioned substances, for preventing and treating diseases, particularly for preventing and treating diseases with an overshooting immune response (autoimmune disease, allergies and transplant rejections), other chronic inflammatory diseases, neuronal diseases and cerebral damages, skin diseases (inter alia, acne and psoriasis), tumor diseases and special viral infections (inter alia, SARS).

Inventors:
ANSORGE SIEGFRIED (DE)
BANK UTE (DE)
NORDHOFF KARSTEN (DE)
TAEGER MICHAEL (DE)
STRIGGOW FRANK (DE)
Application Number:
EP2004011644W
Publication Date:
December 08, 2005
Filing Date:
October 15, 2004
Export Citation:
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Assignee:
IMTM GMBH (DE)
KEYNEUROTEK AG (DE)
International Classes:
A61K31/404; A61K31/4045; C07C233/83; C07C243/28; C07C251/86; C07C327/48; C07D207/327; C07D295/15; C07D307/52; C07D317/58; C07D403/06; C07D405/06; C07D513/04; (IPC1-7): A61K31/404; A61K31/4045; C07C243/28; C07D307/52; C07D207/32; C07D405/06; C07D513/04; C07D317/58
Domestic Patent References:
WO2002053170A22002-07-11
Foreign References:
DE10155093A12003-06-12
US20020198205A12002-12-26
Other References:
TIM BUGNI ET AL.: "p-Sulfooxyphenylpyruvic acid from thered macro algy Ceratodictyon spongiosum and its sponge symbiont and Haliclona cymaeformis", PHYTOCHEMISTRY, vol. 60, no. 4, 2002, pages 361 - 363, XP002328942
MASARU OGATA ET AL: "synthesis and Antifungal properties of a series of Novel 1,2-disubstituted Propenones", J: MED. CHEM, vol. 30, 1987, pages 1497 - 1502, XP002328943
DALE L. BOGER: "Non-amide Based Combinatorial libraries Derived from N-Boc-Iminodiacetic Acid: Solution-Pahase Synthesis of Piperazinone Libraries with Activity Against LEF-1/beta-Catenin-Mediated Transcription", HELVETICA CHEMICA ACTA, vol. 83, 2000, pages 1825 - 1845, XP002328944
SHUBHRA MITTAL (NEE GARG) ET AL: "Structure Activity Relationship of Estrogens: Receptor Affinity and Estrogn Antagonist Activity of Certain (E) and (Z)-1,2,3-Triararyl-2-propen-1-ones", J. MED CHEM, vol. 28, 1985, pages 492 - 497, XP002328945
MARK CUSHMAN ET AL: "Synthesis and Evaluation of Analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenylethene as Potential Cytotoxic and Antimitotic Agent", J. MED. CHEM., vol. 35, 1992, pages 2293 - 2306, XP002328946
PETER C. ASTLES ET AL.: "Selective Endothelin A Receptor Antagonists. 4. Discovery and Structure-Activity Relationsships of Stilbene Acid and Alcohol Derivatives", J. MED. CHEM., vol. 41, 1998, pages 2745 - 2753, XP002328947
NICHOLAS MEANWELL ET AL.: "Nonprostatoid Prostacyclin Mimetics. 4. Derivatives of 2-[3-[2-4,5-Diphenyl-2-oxazolyl)ethyl]phenoxyacetic Acid Substituted alpha to the Oxazole ring", J.MED.CHEM, vol. 36, 1993, pages 3871 - 3883, XP002328948
AUGUSTYNS K ET AL: "THE UNIQUE PROPERTIES OF DIPEPTIDYL-PEPTIDASE IV (DPP IV/CD26) AND THE THERAPEUTIC POTENTIAL OF DPP IV INHIBITORS", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 4, 1999, pages 311 - 327, XP000870290, ISSN: 0929-8673
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