Title:
DUAL CONTROLS FOR THERAPEUTIC CELL ACTIVATION OR ELIMINATION
Document Type and Number:
WIPO Patent Application WO/2017/106185
Kind Code:
A8
Abstract:
The technology relates in part to methods for controlling the activity or elimination of therapeutic cells using molecular switches that employ distinct heterodimerizer ligands, in conjunction with other multimeric ligands. The technology may be used, for example to activate or eliminate cells used to promote engraftment, to treat diseases or condition, or to control or modulate the activity of therapeutic cells that express chimeric antigen receptors or recombinant T cell receptors.
Inventors:
BAYLE JOSEPH (US)
DUONG MYLINH (US)
COLLINSON-PAUTZ MATTHEW (US)
FOSTER AARON (US)
SPENCER DAVID (US)
DUONG MYLINH (US)
COLLINSON-PAUTZ MATTHEW (US)
FOSTER AARON (US)
SPENCER DAVID (US)
Application Number:
PCT/US2016/066371
Publication Date:
June 21, 2018
Filing Date:
December 13, 2016
Export Citation:
Assignee:
BELLICUM PHARMACEUTICALS INC (US)
International Classes:
C07K14/705; A61K48/00; C07K14/47; C12N5/0783
Attorney, Agent or Firm:
SILVERSTEIN, Sheryl R. et al. (US)
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