DUAL FUNCTION PROTEINS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Title:

DUAL FUNCTION PROTEINS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Document Type and Number:

WIPO Patent Application WO/2017/074123

Kind Code:

A1

Abstract:

The present invention provides a dual function protein prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin, which has improved pharmacological efficacy, in vivo duration and protein stability. A dual function protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.

Inventors:

KIM JUN HWAN (KR)
LIM SEYOUNG (KR)
SEO MINJI (KR)
CHOI HYUN HO (KR)
KIM DOHOON (KR)
JU MI KYEONG (KR)
PARK JU-YOUNG (KR)
KIM SEUL GI (KR)
LIM SANGMYOUN (KR)
KIM JONG GYUN (KR)
NAM SU YOUN (KR)

Application Number:

PCT/KR2016/012300

Publication Date:

May 04, 2017

Filing Date:

October 28, 2016

Export Citation:

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Assignee:

YUHAN CORP (KR)

International Classes:

C07K14/50; A61K38/17; A61K38/18; A61K38/26; C07K14/46; C07K14/605; C07K19/00

Domestic Patent References:

WO2009020802A2

2009-02-12

Foreign References:

US20140243503A1	2014-08-28
US20120238496A1	2012-09-20
US20130129724A1	2013-05-23
US20120172298A1	2012-07-05

Other References: