Title:
DUAL-FUNCTIONAL COMPOUNDS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2023/005180
Kind Code:
A1
Abstract:
This disclosure relates a compound configured to release nitric oxide (NO) and inhibit the activity of a phosphodiesterase (PDE) when administered to a subject. The compound may include L 1 and L 2. L 1 may include a functional group that is part or all of a NO releasing agent. L 2 may include a functional group that is part or all of a PDE inhibitor. The compound may further include a bond or a biradical that connects L 1 and L 2. Further provided is a method of treating or preventing a disease using the compound or a composition including the compound.
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Inventors:
HUANG ZHENG (CN)
MA TIANWEI (CN)
XIAO YUE (CN)
MA TIANWEI (CN)
XIAO YUE (CN)
Application Number:
PCT/CN2022/074797
Publication Date:
February 02, 2023
Filing Date:
January 28, 2022
Export Citation:
Assignee:
BIOFRONT THERAPEUTICS BEIJING CO LTD (CN)
International Classes:
C07D209/48; A61K31/4035; A61P11/00; A61P35/00
Domestic Patent References:
| WO1998019672A1 | 1998-05-14 | |||
| WO2012083153A1 | 2012-06-21 |
Foreign References:
| CN113767104A | 2021-12-07 | |||
| CN112566670A | 2021-03-26 | |||
| CN108290896A | 2018-07-17 | |||
| US6331543B1 | 2001-12-18 | |||
| US6133272A | 2000-10-17 |
Other References:
HAROLDO A. FLORES TOQUE, FERNANDA B. M. PRIVIERO, CLEBER E. TEIXEIRA, ELISA PERISSUTTI, FERDINANDO FIORINO, BEATRICE SEVERINO, FRA: "Synthesis and Pharmacological Evaluations of Sildenafil Analogues for Treatment of Erectile Dysfunction", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 51, no. 9, 1 May 2008 (2008-05-01), pages 2807 - 2815, XP055013438, ISSN: 00222623, DOI: 10.1021/jm701400r
Attorney, Agent or Firm:
METIS IP (CHENGDU) LLC (CN)
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