Title:
CDK8/19 DUAL INHIBITORS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2023/078337
Kind Code:
A1
Abstract:
The disclosure provides for compounds and methods for modulating or inhibiting CDK8/19. In one aspect, described herein are compounds of Formula (A'), (A), (A-I), (A-II), (II), (II-I), (II-II), (III), (B), (IV), (V), (VI), and (VII), and salts and solvates thereof. In one aspect, described herein are pharmaceutical compositions comprising a compound described herein, or a salt or solvate thereof. In one aspect, described herein are methods of treating a disease or condition comprising administering a described compound, or a salt or solvate thereof.
Inventors:
LIU YINGTAO (CN)
WU JIANPING (CN)
LIU XIAOSONG (CN)
REN FENG (CN)
WU JIANPING (CN)
LIU XIAOSONG (CN)
REN FENG (CN)
Application Number:
PCT/CN2022/129486
Publication Date:
May 11, 2023
Filing Date:
November 03, 2022
Export Citation:
Assignee:
INSILICO MEDICINE IP LTD (CN)
International Classes:
A61K31/395; C07D249/00; A61P35/00; C07D403/00; C07D413/00; C07D417/00
Domestic Patent References:
| WO2016009076A1 | 2016-01-21 | |||
| WO2018136202A2 | 2018-07-26 | |||
| WO2016041618A1 | 2016-03-24 |
Foreign References:
| EP3666770A1 | 2020-06-17 |
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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