Title:
GITR/TGF-β DUAL-TARGETED FUSION PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/284733
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine, and provides a GITR/TGF-β dual-targeted fusion protein, a conjugate and pharmaceutical composition comprising same, and a use of the fusion protein or conjugate in the preparation of a drug.
Inventors:
ZHOU YAQIONG (CN)
GAO ZHANGZHAO (CN)
WU ZHENHUA (CN)
NIE LEI (CN)
HU FENG (CN)
QI JIAN (CN)
WANG HAIBIN (CN)
GAO ZHANGZHAO (CN)
WU ZHENHUA (CN)
NIE LEI (CN)
HU FENG (CN)
QI JIAN (CN)
WANG HAIBIN (CN)
Application Number:
PCT/CN2022/105175
Publication Date:
January 19, 2023
Filing Date:
July 12, 2022
Export Citation:
Assignee:
HISUN BIOPHARMACEUTICAL CO LTD (CN)
BIORAY PHARMACEUTICAL CO LTD (CN)
BIORAY PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K19/00; A61K9/00; A61K38/17; A61K45/00; A61K47/64; A61P35/00; A61P35/02; A61P37/04; C12N5/10; C12N15/62
Domestic Patent References:
| WO2020033715A1 | 2020-02-13 | |||
| WO2021093760A1 | 2021-05-20 |
Foreign References:
| CN113429488A | 2021-09-24 | |||
| CN102203258A | 2011-09-28 | |||
| CN108026158A | 2018-05-11 |
Other References:
LI SHENG QING , LI HUAN ZHANG , YANG QIAO XIN , NI DIAN TAO: "Purification and characterization of the fusion protein TGF-βRⅡ/Fc", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 19, no. 4, 30 August 2003 (2003-08-30), pages 400 - 402+405, XP093023988, ISSN: 1007-8738
YOO CHANGHOON, OH DO-YOUN, CHOI HYE JIN, KUDO MASATOSHI, UENO MAKOTO, KONDO SHUNSUKE, CHEN LI-TZONG, OSADA MOTONOBU, HELWIG CHRIST: "Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 1 January 2020 (2020-01-01), pages 1 - 9, XP093023991, DOI: 10.1136/jitc-2020-000564
YOO CHANGHOON, OH DO-YOUN, CHOI HYE JIN, KUDO MASATOSHI, UENO MAKOTO, KONDO SHUNSUKE, CHEN LI-TZONG, OSADA MOTONOBU, HELWIG CHRIST: "Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 1 January 2020 (2020-01-01), pages 1 - 9, XP093023991, DOI: 10.1136/jitc-2020-000564
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