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Title:
DUAL-TARGETING COMPOUND AGAINST FIBROBLAST ACTIVATION PROTEIN FAP AND INTEGRIN αVβ3, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067531
Kind Code:
A1
Abstract:
Provided is a dual-targeting compound against FAP and integrin αvβ3. The targeting compound and a radionuclide marker thereof can synergistically target a FAP target and an integrin αvβ3 target in tumors, such that the number of and the utilization efficiency of effective receptors in tumors can be increased. Also provided are a radionuclide marker on the basis of the targeting compound, and a preparation method therefor and use thereof in the diagnosis or treatment of a disease characterized by excessive expression of fibroblast activation protein (FAP) and/or integrin αvβ3.

Inventors:
CHEN XIAOYUAN (CN)
XU PENGFEI (CN)
WU XIAOMING (CN)
GUO ZHIDE (CN)
YANG QINGBAO (CN)
WEN XUEJUN (CN)
Application Number:
PCT/CN2023/121284
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
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Assignee:
YANTAI LANNACHENG BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K7/64; A61K38/08; A61P9/10; A61P17/02; A61P29/00; A61P35/00; C07K1/04
Domestic Patent References:
WO2023098920A12023-06-08
Foreign References:
CN115505032A2022-12-23
CN116751259A2023-09-15
CN114984255A2022-09-02
CN113621021A2021-11-09
CN110420337A2019-11-08
CN111699181A2020-09-22
CN113164630A2021-07-23
CN113292538A2021-08-24
CN113603678A2021-11-05
CN113880810A2022-01-04
Other References:
ZANG JIE, WEN XUEJUN, LIN RONG, ZENG XINYING, WANG CHAO, SHI MENGQI, ZENG XUEYUAN, ZHANG JIAYING, WU XIAOMING, ZHANG XIANZHONG, MI: "Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [ 68 Ga]Ga-FAPI-RGD", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 12, no. 16, 1 January 2022 (2022-01-01), AU , pages 7180 - 7190, XP093151735, ISSN: 1838-7640, DOI: 10.7150/thno.79144
Attorney, Agent or Firm:
BEIJING ZHAOJUN UNION INTELLECTUAL PROPERTY LAW FIRM (CN)
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