DURLOBACTAM CRYSTALLINE FORMS - ENTASIS THERAPEUTICS LTD

Title:

DURLOBACTAM CRYSTALLINE FORMS

Document Type and Number:

WIPO Patent Application WO/2023/206580

Kind Code:

A1

Abstract:

Provided herein are salt forms of Durlobactam (DUR) having the Formula I: In particular, crystalline forms of a DUR-TBA, a DUR-TEA, and a DUR-Ca are provided. The methods of preparing these salts, and characterization of their various polymorphic forms are also provided. Additionally, the present invention comprises methods for synthesizing the DUR-Na from the various crystalline DUR salts disclosed.

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Inventors:

DURAND-REVILLE THOMAS FRANCOIS (US)
WU FRANK (CN)
LIAO XIAOMING (CN)
WANG XIAONA (CN)
ZHANG SIXING (CN)

Application Number:

PCT/CN2022/090815

Publication Date:

November 02, 2023

Filing Date:

April 29, 2022

Export Citation:

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Assignee:

ENTASIS THERAPEUTICS LTD (GB)
DURAND REVILLE THOMAS FRANCOIS (US)
WU FRANK (CN)
LIAO XIAOMING (CN)
WANG XIAONA (CN)
ZHANG SIXING (CN)

International Classes:

C07D471/08

Domestic Patent References:

WO2013150296A1	2013-10-10
WO2016081452A1	2016-05-26
WO2013150296A1	2013-10-10
WO2018053215A1	2018-03-22

Attorney, Agent or Firm:

KING & WOOD MALLESONS (CN)

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