Title:
DYES FOR ANALYSIS OF PROTEIN AGGREGATION
Document Type and Number:
WIPO Patent Application WO/2011/065980
Kind Code:
A3
Abstract:
Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
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Inventors:
PATTON WAYNE FORREST (US)
YARMOLUK SERGIY M (UA)
PANDE PRAVEEN (US)
KOVALSKA VLADYSLAVA (UA)
DAI LIJUN (US)
VOLKOVA KATERYNA (UA)
COLEMAN JACK (US)
LOSYTSKYY MYKHAYLO (UA)
LUDLAM ANTHONY (US)
BALANDA ANATOLIY (UA)
SHEN DEE (US)
YARMOLUK SERGIY M (UA)
PANDE PRAVEEN (US)
KOVALSKA VLADYSLAVA (UA)
DAI LIJUN (US)
VOLKOVA KATERYNA (UA)
COLEMAN JACK (US)
LOSYTSKYY MYKHAYLO (UA)
LUDLAM ANTHONY (US)
BALANDA ANATOLIY (UA)
SHEN DEE (US)
Application Number:
PCT/US2010/003061
Publication Date:
November 17, 2011
Filing Date:
November 30, 2010
Export Citation:
Assignee:
ENZO LIFE SCIENCES INC (US)
PATTON WAYNE FORREST (US)
YARMOLUK SERGIY M (UA)
PANDE PRAVEEN (US)
KOVALSKA VLADYSLAVA (UA)
DAI LIJUN (US)
VOLKOVA KATERYNA (UA)
COLEMAN JACK (US)
LOSYTSKYY MYKHAYLO (UA)
LUDLAM ANTHONY (US)
BALANDA ANATOLIY (UA)
SHEN DEE (US)
PATTON WAYNE FORREST (US)
YARMOLUK SERGIY M (UA)
PANDE PRAVEEN (US)
KOVALSKA VLADYSLAVA (UA)
DAI LIJUN (US)
VOLKOVA KATERYNA (UA)
COLEMAN JACK (US)
LOSYTSKYY MYKHAYLO (UA)
LUDLAM ANTHONY (US)
BALANDA ANATOLIY (UA)
SHEN DEE (US)
International Classes:
C09B23/14; G01N33/68
Domestic Patent References:
| WO2009109457A2 | 2009-09-11 | |||
| WO2007110538A2 | 2007-10-04 | |||
| WO2007110542A2 | 2007-10-04 |
Foreign References:
| GB2011457A | 1979-07-11 | |||
| FR2912140A1 | 2008-08-08 | |||
| DE3136259A1 | 1983-03-24 | |||
| CH648859A5 | 1985-04-15 |
Other References:
DEMEULE ET AL: "Detection and characterization of protein aggregates by fluorescence microscopy", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 329, no. 1-2, 20 December 2006 (2006-12-20), pages 37 - 45, XP005809171, ISSN: 0378-5173, DOI: DOI:10.1016/J.IJPHARM.2006.08.024
KOVALSKA V B ET AL: "Fluorescent homodimer styrylcyanines: synthesis and spectral-luminescent studies in nucleic acids and protein complexes", DYES AND PIGMENTS, ELSEVIER APPLIED SCIENCE PUBLISHERS. BARKING, GB, vol. 67, no. 1, 1 October 2005 (2005-10-01), pages 47 - 54, XP025281107, ISSN: 0143-7208, [retrieved on 20051001], DOI: DOI:10.1016/J.DYEPIG.2004.10.007
KOVALSKA V B ET AL: "Studies on the Spectral-Luminescent Properties of the Novel Homodimer Styryl Dyes in Complexes with DNA", JOURNAL OF FLUORESCENCE, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 15, no. 3, 1 May 2005 (2005-05-01), pages 215 - 219, XP019281685, ISSN: 1573-4994
KOVALSKA V B ET AL: "Fluorescent homodimer styrylcyanines: synthesis and spectral-luminescent studies in nucleic acids and protein complexes", DYES AND PIGMENTS, ELSEVIER APPLIED SCIENCE PUBLISHERS. BARKING, GB, vol. 67, no. 1, 1 October 2005 (2005-10-01), pages 47 - 54, XP025281107, ISSN: 0143-7208, [retrieved on 20051001], DOI: DOI:10.1016/J.DYEPIG.2004.10.007
KOVALSKA V B ET AL: "Studies on the Spectral-Luminescent Properties of the Novel Homodimer Styryl Dyes in Complexes with DNA", JOURNAL OF FLUORESCENCE, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 15, no. 3, 1 May 2005 (2005-05-01), pages 215 - 219, XP019281685, ISSN: 1573-4994
Attorney, Agent or Firm:
GENDLOFF, Elie (Inc.527 Madison Avenue, 9th Floo, New York NY, US)
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