Title:
DYNAMIC SIGNAL SELECTION IN CHROMATOGRAPHY/MASS SPECTROMETRY/MASS SPECTROMETRY SYSTEM
Document Type and Number:
WIPO Patent Application WO2004090933
Kind Code:
A3
Abstract:
A method and system for obtaining mass spectrographic data of a substance. The method includes (a) subjecting the substance to a chromatographic process and ionizing the output thereof; (b) obtaining a current mass spectrogram of the output; (c) identifying at least one ion having a fast rising mass signal by comparing the current mass spectrum obtained in step (b) against one or more previously acquired mass spectrums of the output; and (d) fragmenting the identified ion and recording a mass spectrum resulting therefrom. A mass spectrometer system, includes a chromatography column; a mass spectrometer, including an ion source for ionizing the output of the chromatographic column, in which the mass spectrometer is capable of isolating, fragmenting and mass analyzing an ion of selected mass; and a data-dependent, data acquisition controller programmed to operate the mass spectrometer so as to obtain a current mass spectrogram of the output, identify one or more ions having fast rising mass signals by comparing the current mass spectrum against one or more previously acquired mass spectra of the output, and fragmenting of said identified ions and recording a mass spectrum resulting therefrom.
Inventors:
LE BLANC YVES (CA)
Application Number:
PCT/CA2004/000540
Publication Date:
July 21, 2005
Filing Date:
April 08, 2004
Export Citation:
Assignee:
MDS INC DBA MDS SCIEX (CA)
LE BLANC YVES (CA)
LE BLANC YVES (CA)
International Classes:
G01N30/86; H01J49/00; H01J49/02; H01J49/04; G01N30/72; (IPC1-7): H01J49/02
Domestic Patent References:
| WO1999038193A1 | 1999-07-29 |
Foreign References:
| US20010052569A1 | 2001-12-20 | |||
| US20020023078A1 | 2002-02-21 | |||
| EP1006559A2 | 2000-06-07 | |||
| EP0887646A1 | 1998-12-30 | |||
| US6147344A | 2000-11-14 |
Other References:
FRANK M: "Mass spectrometry with cryogenic detectors", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, NORTH-HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. 444, no. 1-2, April 2000 (2000-04-01), pages 375 - 384, XP004196437, ISSN: 0168-9002
JORDANOV V T ET AL: "Compact circuit for pulse rise-time discrimination", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, NORTH-HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. 380, no. 1-2, 1 October 1996 (1996-10-01), pages 353 - 357, XP004206376, ISSN: 0168-9002
JORDANOV V T ET AL: "Compact circuit for pulse rise-time discrimination", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, NORTH-HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. 380, no. 1-2, 1 October 1996 (1996-10-01), pages 353 - 357, XP004206376, ISSN: 0168-9002
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