Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
(E)-α,β-UNSATURATED AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/042301
Kind Code:
A1
Abstract:
The present invention provides a new class of (E)-α,β-unsaturated amide compounds represented by formula I, and also relates to methods for preparing such compounds and the pharmaceutical uses thereof. The compounds have the effect of protecting nerve cells and an immunoregulatory activity. The definitions of R1, R2 and R3 in formula I are given in the description.

Inventors:
ZHAO XUYANG (CN)
BAI HUA (CN)
GONG YONGXIANG (CN)
LIU LIFEI (CN)
ZHONG JINQING (CN)
ZHANG XINLONG (CN)
FENG RENTIAN (CN)
JI KAIGE (CN)
DING FANG (CN)
LIU WEIWEI (CN)
LI YI (CN)
CHEN WEN (CN)
GONG YOUJING (CN)
ZHU YONGLIN (CN)
Application Number:
CN2018/102824
Publication Date:
March 07, 2019
Filing Date:
August 29, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07C225/14; A61P25/00; A61P29/00; A61P37/00; C07C211/02; C07C291/02; C07D207/18; C07D211/68; C07D263/30; C07D295/088
Foreign References:
CN104169261A2014-11-26
CN105452213A2016-03-30
US6414013B12002-07-02
Other References:
X.JING: "Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity", NEUROSCIENCE, vol. 286, 12 February 2015 (2015-02-12), XP029188354, ISSN: 0306-4522, DOI: doi:10.1016/j.neuroscience.2014.11.047
LI NA ET AL: "Application and Mechanism of Dimethylfnmarate in MS: Research Progress", MILITARY MEDICAL SCIENCES, vol. 39, no. 11, 30 November 2015 (2015-11-30)
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
Download PDF: