Title:
EASILY PURIFIABLE SYNTHON COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2013/144301
Kind Code:
A3
Abstract:
The present invention relates to an improved [18F] labelled synthon composition, wherein the non-radioactive impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F] labelled synthon. The resultant purified [18F] label led synthon therefore can be used in the production of a positron emission tomography (PET) tracer having improved properties for in vivo imaging. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
Inventors:
BHALLA RAJIV (AU)
JACKSON ALEXANDER (GB)
SMITH GARETH (GB)
JACKSON ALEXANDER (GB)
SMITH GARETH (GB)
Application Number:
PCT/EP2013/056720
Publication Date:
November 21, 2013
Filing Date:
March 28, 2013
Export Citation:
Assignee:
GE HEALTHCARE LTD (GB)
International Classes:
A61K51/04; A61K51/12; C07B59/00
Domestic Patent References:
| WO2011141515A1 | 2011-11-17 | |||
| WO2010066380A1 | 2010-06-17 | |||
| WO2009127372A1 | 2009-10-22 | |||
| WO2008022319A2 | 2008-02-21 |
Other References:
LINJING MU ET AL: "18F-Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2012, no. 5, 2 February 2012 (2012-02-02), pages 889 - 892, XP055078259, ISSN: 1434-193X, DOI: 10.1002/ejoc.201101730
FALGUNI BASULI ET AL: "Syntheses of meta-[18F]fluorobenzaldehyde and meta-[18F]fluorobenzylbromide from phenyl(3-Formylphenyl) iodonium salt precursors", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 54, no. 4, 17 April 2011 (2011-04-17), pages 224 - 228, XP055071325, ISSN: 0362-4803, DOI: 10.1002/jlcr.1853
ERMERT J ET AL: "Comparison of pathways to the versatile synthon of no-carrier-added 1-bromo-4-[18F]fluorobenzene", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 47, 1 June 2004 (2004-06-01), pages 429 - 441, XP002673773, ISSN: 0362-4803, [retrieved on 20040505], DOI: 10.1002/JLCR.830
JOONG-HYUN CHUN ET AL: "Regiospecific Syntheses of Functionalized Diaryliodonium Tosylates via [Hydroxy(tosyloxy)iodo]arenes Generated in Situ from (Diacetoxyiodo)arenes", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 77, no. 4, 17 February 2012 (2012-02-17), pages 1931 - 1938, XP055071361, ISSN: 0022-3263, DOI: 10.1021/jo202517v
FALGUNI BASULI ET AL: "Syntheses of meta-[18F]fluorobenzaldehyde and meta-[18F]fluorobenzylbromide from phenyl(3-Formylphenyl) iodonium salt precursors", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 54, no. 4, 17 April 2011 (2011-04-17), pages 224 - 228, XP055071325, ISSN: 0362-4803, DOI: 10.1002/jlcr.1853
ERMERT J ET AL: "Comparison of pathways to the versatile synthon of no-carrier-added 1-bromo-4-[18F]fluorobenzene", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 47, 1 June 2004 (2004-06-01), pages 429 - 441, XP002673773, ISSN: 0362-4803, [retrieved on 20040505], DOI: 10.1002/JLCR.830
JOONG-HYUN CHUN ET AL: "Regiospecific Syntheses of Functionalized Diaryliodonium Tosylates via [Hydroxy(tosyloxy)iodo]arenes Generated in Situ from (Diacetoxyiodo)arenes", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 77, no. 4, 17 February 2012 (2012-02-17), pages 1931 - 1938, XP055071361, ISSN: 0022-3263, DOI: 10.1021/jo202517v
Attorney, Agent or Firm:
BANNAN, Sally et al. (Pollards WoodNightingales Lane,Chalfont St Giles, Buckinghamshire HP8 4SP, GB)
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