EB MATRIX PRODUCTION FROM FETAL TISSUES AND ITS USE FOR TISSUE REPAIR

Title:

EB MATRIX PRODUCTION FROM FETAL TISSUES AND ITS USE FOR TISSUE REPAIR

Document Type and Number:

WIPO Patent Application WO2002096263

Kind Code:

A3

Abstract:

A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The process includes, but is not limited to, harvesting the tissue, optionally extracting growth and differentiation factors from the tissue, inactivating infective agents of the tissue, mechanically expressing undesirable components from the tissue, delipidizing the tissue, washing the tissue, optionally drying the tissue and optionally cross-linking the tissue not necessarily in the order described. The resulting product, EBM, is characterized by its microbial, fungal, viral and prion inactivated state. EBM is strong, bioremodelable, drapable and does not undergo calcification. EBM supplants previous inventions because of its unique method of preparation and broad applicability in tissue reengineering.

Inventors:

DAI JIANWU
BELL EUGENE
RUSSAKOVSKY VLADIMIR

Application Number:

PCT/US2002/015620

Publication Date:

March 04, 2004

Filing Date:

May 20, 2002

Export Citation:

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Assignee:

TEI BIOSCIENCES INC (US)

International Classes:

A61L27/00; A61K35/12; A61K35/44; A61L27/36; C12N5/08; (IPC1-7): A61F2/00; A01N1/02; C12N5/06; C12N5/08; C12N11/02; A01N33/48

Foreign References:

US6179872B1	2001-01-30
US4801299A	1989-01-31

Other References: